{"id":"W4387446403","doi":"10.1212/nxi.0000000000200167","title":"Increasing Neurofilament and Glial Fibrillary Acidic Protein After Treatment Discontinuation Predicts Multiple Sclerosis Disease Activity","year":2023,"lang":"en","type":"article","venue":"Neurology Neuroimmunology & Neuroinflammation","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Sanofi Genzyme; EMD Serono; National Institutes of Health; Genentech; Multiple Sclerosis Society; Multiple Sclerosis Society of Canada; MedDay Pharmaceuticals; Biogen; Celgene; Cure Alzheimer's Fund; U.S. Department of Defense; Sanofi; Verily Life Sciences; Bristol-Myers Squibb","keywords":"Glial fibrillary acidic protein; Multiple sclerosis; Discontinuation; Neurofilament; Disease; Medicine; Chemistry; Pathology; Internal medicine; Immunology; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006577878,0.000182292,0.0002689699,0.0003187158,0.0002729157,0.0003446686,0.0001759119,0.0002894284,0.002038001],"category_scores_gemma":[0.001953881,0.0001210567,0.0003606979,0.000347849,0.0001570093,0.000243921,0.0001982226,0.0004088434,0.0001994593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002048629,"about_ca_system_score_gemma":0.0001936732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002201385,"about_ca_topic_score_gemma":0.002590833,"domain_scores_codex":[0.9996551,0.00009722477,0.00004454229,0.00006341637,0.00006781003,0.00007183907],"domain_scores_gemma":[0.997195,0.0004656578,0.001794642,0.00009664129,0.0001596348,0.0002883135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002950348,0.00002906146,0.9980628,0.000005142357,0.00003056963,0.00002335978,0.00001446761,0.00002964917,0.0002255464,0.00000273649,0.00008563301,0.001195931],"study_design_scores_gemma":[0.00001208602,0.0001334256,0.9993477,0.000002466968,0.00001795001,0.000108599,0.00002091999,0.0001784675,0.00009025029,0.000005703608,0.00008079206,0.000001549664],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991825,0.0001943847,0.00006934763,0.00004623731,0.000005026713,0.000006466552,0.0002063317,0.000004790608,0.0002848939],"genre_scores_gemma":[0.9996113,0.00003193484,0.00004346925,0.00002523201,0.00001052349,0.000005056233,0.0001672218,9.878362e-7,0.0001044041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002201385,"threshold_uncertainty_score":0.006817818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04628236456953838,"score_gpt":0.2698799443217441,"score_spread":0.2235975797522057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}