{"id":"W4387448223","doi":"10.7554/elife.89176.2.sa1","title":"Reviewer #2 (Public Review): Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function","year":2023,"lang":"en","type":"peer-review","venue":"","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Erythropoietin-producing hepatocellular (Eph) receptor; Ephrin; Receptor tyrosine kinase; Cell biology; Receptor Protein-Tyrosine Kinases; Biology; Ubiquitin ligase; Signal transduction; EPH receptor A2; Ubiquitin; Chemical genetics; Receptor; Tyrosine kinase; Effector; Biochemistry; Small molecule","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01394961,0.001419,0.002430771,0.003079093,0.002043744,0.006580697,0.004248135,0.01680667,0.08041736],"category_scores_gemma":[0.07250948,0.0009353997,0.002208127,0.001618121,0.001495578,0.00360516,0.002712308,0.005921681,0.05241924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004948096,"about_ca_system_score_gemma":0.008243731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002151094,"about_ca_topic_score_gemma":0.003308562,"domain_scores_codex":[0.9908726,0.001933703,0.001171271,0.001165959,0.004047741,0.0008087184],"domain_scores_gemma":[0.8871778,0.007686022,0.004875003,0.002939218,0.08940779,0.007914208],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002353908,0.000003354742,0.00003778154,0.0003307003,0.00000708247,0.00002543655,0.000006605807,0.00000792186,0.00004595872,0.00007428649,0.9954152,0.004022144],"study_design_scores_gemma":[0.0001272886,0.00005191388,0.0008318053,0.001312133,0.00004798384,0.0003245776,0.00004559786,0.000077141,0.0002238307,0.0005512017,0.9963719,0.00003465216],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"commentary","genre_scores_codex":[0.0002484975,0.01280486,0.0006836135,0.2517678,0.7233574,0.0004877512,0.001549751,0.0005594826,0.008540843],"genre_scores_gemma":[0.004689798,0.01819115,0.0009574123,0.3002333,0.6024247,0.001530305,0.001862297,0.0006822642,0.06942884],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.9860504,"threshold_uncertainty_score":0.2690229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1139042136240199,"score_gpt":0.3339576431450933,"score_spread":0.2200534295210734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}