{"id":"W4387448637","doi":"10.1073/pnas.2308204120","title":"Progenitor division and cell autonomous neurosecretion are required for rod photoreceptor sublaminar positioning","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Ontario; Canada Research Chairs; Canada First Research Excellence Fund; Krembil Foundation; Government of Canada","keywords":"Biology; Cell biology; Soma; Retina; Cell division; Progenitor cell; Chromosomal translocation; Anatomy; Neuroscience; Cell; Stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008450612,0.0003389316,0.0002018042,0.0001771258,0.0002423208,0.0005067728,0.0001982827,0.0002574194,0.000787857],"category_scores_gemma":[0.0001306484,0.0002651406,0.0001598855,0.0001085956,0.0003098058,0.0002348358,0.0004223416,0.0004595321,0.0005645652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004434095,"about_ca_system_score_gemma":0.0004337663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009801124,"about_ca_topic_score_gemma":0.00230293,"domain_scores_codex":[0.9998484,0.00001033244,0.00001317329,0.00003534634,0.00006543178,0.00002725478],"domain_scores_gemma":[0.9998435,0.00001437018,0.00004832137,0.00001593246,0.0000153723,0.00006255523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003053462,0.000005932631,0.0003517858,0.00001375832,0.000001314911,0.00004603705,0.000009577415,0.00001526059,0.9983649,0.0001558534,0.00001652492,0.0009884861],"study_design_scores_gemma":[0.000009570665,0.0000654526,0.02756919,0.000004926612,0.00001117686,0.000333677,0.00005390339,0.0009016318,0.9673777,0.0001396113,0.003529053,0.000004021724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918925,0.001664798,0.003868565,0.00008690816,0.00002208955,0.00001423745,0.0002649328,0.0001248396,0.002061103],"genre_scores_gemma":[0.9930928,0.0006614783,0.001624561,0.0000329216,0.00000686364,0.00001928829,0.0004962059,0.00003220768,0.004033651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009801124,"threshold_uncertainty_score":0.00321722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02343792727805733,"score_gpt":0.2787620064801279,"score_spread":0.2553240792020706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}