{"id":"W4387448637","doi":"10.1073/pnas.2308204120","title":"Progenitor division and cell autonomous neurosecretion are required for rod photoreceptor sublaminar positioning","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Ontario; Canada Research Chairs; Canada First Research Excellence Fund; Krembil Foundation; Government of Canada","keywords":"Biology; Cell biology; Soma; Retina; Cell division; Progenitor cell; Chromosomal translocation; Anatomy; Neuroscience; Cell; Stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000444814,0.00005901322,0.00006300196,0.00006328297,0.0001768978,0.00001934172,0.0001925496,0.00005909125,0.000001079707],"category_scores_gemma":[0.0002161262,0.00004440215,0.0000398263,0.0002314346,0.0001811076,0.00001975156,0.00008946357,0.00002999337,3.894243e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005939624,"about_ca_system_score_gemma":0.00001968687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":6.976351e-7,"about_ca_topic_score_gemma":2.090918e-8,"domain_scores_codex":[0.9992871,0.000003278294,0.00014553,0.0001903456,0.0002750696,0.00009873709],"domain_scores_gemma":[0.9996219,0.00001894953,0.000196513,0.000004639507,0.0001389461,0.00001909268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002514798,0.00001154006,0.01301212,0.00005218005,0.000003143907,1.403991e-9,0.00004492571,0.00001212056,0.9855915,0.000376749,0.0006876711,0.0001828636],"study_design_scores_gemma":[0.000177335,0.0001099291,0.1212214,0.00002978819,0.000004545145,0.000001127254,0.0001620744,0.0005379185,0.8749543,0.00227969,0.0004597272,0.00006215125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984999,0.00008587358,0.000003707234,0.0007380307,0.00002218756,0.0002104865,0.00001171484,0.000006877424,0.0004211939],"genre_scores_gemma":[0.9989292,0.00004878954,0.0006655704,0.00006268725,0.00004434338,0.00002292348,0.000003218139,0.000003845214,0.0002194376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1106372,"threshold_uncertainty_score":0.1810667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02343792727805733,"score_gpt":0.2787620064801279,"score_spread":0.2553240792020706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}