{"id":"W4387449173","doi":"10.1021/acsomega.3c05147","title":"Formation of CoA Adducts of Short-Chain Fluorinated Carboxylates Catalyzed by Acyl-CoA Synthetase from <i>Gordonia</i> sp. Strain NB4-1Y","year":2023,"lang":"en","type":"article","venue":"ACS Omega","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Thompson Rivers University","funders":"Natural Sciences and Engineering Research Council of Canada; Strategic Environmental Research and Development Program","keywords":"Catalysis; Strain (injury); Adduct; Chemistry; Acyl-CoA; Stereochemistry; Medicinal chemistry; Organic chemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002859336,0.0005348955,0.0004529557,0.0001983833,0.0001376142,0.0002991696,0.0003139123,0.0002793465,0.0004859931],"category_scores_gemma":[0.0002809812,0.0001527367,0.0003741621,0.0003525629,0.0002224777,0.0002395783,0.0002987105,0.0005071601,0.0003684765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004127423,"about_ca_system_score_gemma":0.000415673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007506043,"about_ca_topic_score_gemma":0.006677927,"domain_scores_codex":[0.9996854,0.00003561443,0.00003896691,0.00007498501,0.0001075049,0.00005750934],"domain_scores_gemma":[0.9998478,0.00002730669,0.0000362845,0.00002061103,0.00004425434,0.00002379584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003073048,0.00001148948,0.0003505815,0.00001865003,0.000004262864,0.00002603284,0.00001277564,0.00002855328,0.9988989,0.00002145534,0.00002279086,0.0005737992],"study_design_scores_gemma":[0.000003998462,0.0000971897,0.004022861,0.000004177432,0.000010039,0.0000880947,0.00004745061,0.00070834,0.9941018,0.00002121443,0.000887712,0.000006981113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991345,0.0005962029,0.005348116,0.0001846091,0.00004809877,0.00003069956,0.001016633,0.0001258076,0.001304759],"genre_scores_gemma":[0.9729854,0.0009430437,0.01441385,0.00008209405,0.00001352266,0.00005149259,0.005192754,0.00009966384,0.006218182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007506043,"threshold_uncertainty_score":0.01492471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01805013240160981,"score_gpt":0.2573762691752896,"score_spread":0.2393261367736798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}