{"id":"W4387451572","doi":"10.1038/s41467-023-41986-0","title":"A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Universität Zürich","keywords":"Islet; Monoclonal antibody; Antibody; Beta cell; Amyloid (mycology); In vitro; Chemistry; Genetically modified mouse; Apoptosis; Diabetes mellitus; Biochemistry; Transgene; Cell biology; Endocrinology; Medicine; Biology; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000324417,0.0005530983,0.0004808499,0.0004598046,0.000167066,0.0003140254,0.0004511923,0.0006285069,0.001389339],"category_scores_gemma":[0.0001210185,0.0001907759,0.0003684747,0.0002473274,0.0001920395,0.0002523322,0.0001754594,0.001232193,0.0003668257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000238181,"about_ca_system_score_gemma":0.0003120548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004270019,"about_ca_topic_score_gemma":0.0005429801,"domain_scores_codex":[0.9997827,0.00004114906,0.00001780245,0.00004878619,0.00005242351,0.00005713995],"domain_scores_gemma":[0.999895,0.00001347344,0.00002141438,0.00001847204,0.00001534345,0.00003622142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004171413,0.0003809516,0.0001846553,0.00005533818,0.00001726958,0.00006443931,0.00001523336,0.00007144805,0.9940358,0.0001232571,0.0001698825,0.004464603],"study_design_scores_gemma":[0.0003323684,0.006002445,0.005149099,0.00003138824,0.0001086895,0.001006932,0.00002543871,0.001235956,0.9764591,0.0001275984,0.009509238,0.00001177259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782532,0.005577557,0.01055017,0.000351693,0.0002095393,0.0001795874,0.0003852037,0.0004817594,0.004011258],"genre_scores_gemma":[0.9819687,0.00409617,0.007676222,0.0003141526,0.000103457,0.0001873963,0.001105709,0.00006723473,0.004480888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001389339,"threshold_uncertainty_score":0.004647732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04027391191876476,"score_gpt":0.3284298739826199,"score_spread":0.2881559620638551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}