{"id":"W4387453139","doi":"10.1101/2023.10.05.561079","title":"Early nuclear phenotypes and reactive transformation in human iPSC-derived astrocytes from ALS patients with <i>SOD1</i> mutations","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canada First Research Excellence Fund; Fondation Brain Canada; ALS Society of Canada; McGill University","keywords":"SOD1; Induced pluripotent stem cell; Amyotrophic lateral sclerosis; Phenotype; Biology; Astrocyte; Astrogliosis; Cell biology; Oxidative stress; Mutation; Superoxide dismutase; Genetics; Gene; Neuroscience; Pathology; Biochemistry; Medicine; Disease; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001552236,0.0002184884,0.0001438741,0.0002036727,0.0001523309,0.0002225407,0.00009464593,0.0002600168,0.001124697],"category_scores_gemma":[0.0001391065,0.00009054283,0.0001925904,0.0001090593,0.0001520233,0.00007364449,0.0002164249,0.0003301575,0.0006004337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008412021,"about_ca_system_score_gemma":0.00007599855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003556359,"about_ca_topic_score_gemma":0.0003239837,"domain_scores_codex":[0.9998803,0.0000197481,0.00002142003,0.000022981,0.0000419335,0.00001353819],"domain_scores_gemma":[0.9998966,0.00001565031,0.00002640021,0.00001801489,0.00001912761,0.00002423264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001494763,0.00002930629,0.001725274,0.00001633074,0.000005868428,0.0006561578,0.00007790915,0.00006875111,0.9958331,0.0001074715,0.00003640766,0.001294055],"study_design_scores_gemma":[0.00004822736,0.0004796113,0.04090547,0.00001170818,0.00003888898,0.007122759,0.000180021,0.00127455,0.946186,0.0002413204,0.003501233,0.00001008355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940539,0.0002258462,0.003185091,0.00004204041,0.00002507075,0.0000309488,0.0004957125,0.00005704223,0.001884316],"genre_scores_gemma":[0.9954417,0.0002105598,0.00178526,0.0000337885,0.000006110223,0.00003365854,0.001084591,0.00002239618,0.001381991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001124697,"threshold_uncertainty_score":0.003762543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01865851811093261,"score_gpt":0.2378951115715426,"score_spread":0.21923659346061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}