{"id":"W4387460225","doi":"10.1101/2023.10.06.561156","title":"Pharmacological cAMP stimulation via prostaglandin receptors rescues ciliary defects in CEP290-deficient human and mouse models","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Association Nationale de la Recherche et de la Technologie; Retina France; Agence Nationale de la Recherche; Hamilton Health Sciences Foundation; Institut des maladies génétiques Imagine","keywords":"Cilium; Ciliopathies; Retinal degeneration; Joubert syndrome; Biology; Cell biology; Retina; Nephronophthisis; Retinal; Neuroscience; Gene; Genetics; Phenotype; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003402948,0.0005576387,0.0003837596,0.0005101573,0.0002380012,0.0003620704,0.0004104771,0.0007106009,0.002456172],"category_scores_gemma":[0.0001851082,0.0001904422,0.0004819813,0.0001728393,0.0004874041,0.000221374,0.0002459182,0.001142294,0.0009349283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003214985,"about_ca_system_score_gemma":0.0003695099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001220236,"about_ca_topic_score_gemma":0.001582381,"domain_scores_codex":[0.9997419,0.0000325241,0.00003586266,0.00005580438,0.00008677742,0.00004722526],"domain_scores_gemma":[0.9997846,0.00002892165,0.00004949513,0.00003353646,0.0000190378,0.00008434877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002947272,0.0001017016,0.00008820956,0.0000499719,0.000008810433,0.0002363834,0.00001286522,0.00007998382,0.9973877,0.0001411154,0.000231256,0.001367329],"study_design_scores_gemma":[0.0001020787,0.001049247,0.002179711,0.00002157325,0.00003486822,0.0009105089,0.00004875825,0.0009723411,0.9884614,0.0001051555,0.006102689,0.00001174187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742803,0.004485271,0.009914592,0.0006678983,0.0003718264,0.0002306582,0.004391919,0.0007712083,0.004886362],"genre_scores_gemma":[0.9773818,0.003555551,0.006169844,0.0002276424,0.00005187915,0.0002091593,0.00276235,0.0001258977,0.009515905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002456172,"threshold_uncertainty_score":0.008216679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02264227889691433,"score_gpt":0.2525411677932821,"score_spread":0.2298988888963677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}