{"id":"W4387460339","doi":"10.1101/2023.10.05.560956","title":"ABI3 deletion in TgCRND8 mice is associated with reduced amyloid plaque pathology and altered glial response","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Canadian Institutes of Health Research; Alzheimer Society; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"Microglia; Genetically modified mouse; Gene knockin; Biology; Alzheimer's disease; Amyloid (mycology); Transgene; Pathology; Loss function; Amyloid precursor protein; Neuroscience; Genetics; Immunology; Gene; Phenotype; Medicine; Disease; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008818949,0.0005048392,0.000479135,0.0003165362,0.0001190694,0.0001022973,0.0003492303,0.001015649,0.00001426005],"category_scores_gemma":[0.0009041856,0.0005606428,0.00009678396,0.0003430606,0.0001712316,0.00001356031,0.000480619,0.0007883481,0.00002575154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002235012,"about_ca_system_score_gemma":0.0005732917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001116824,"about_ca_topic_score_gemma":0.00007978664,"domain_scores_codex":[0.9969115,0.000529549,0.0005076791,0.001295225,0.0002191249,0.0005369222],"domain_scores_gemma":[0.9980165,0.00008091365,0.0004201289,0.0009194604,0.0003937908,0.0001692268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001078889,0.0001054956,0.002309063,0.00005450493,0.0001601141,0.0001614349,0.00002183807,0.00004214474,0.9954898,0.000008125607,0.0005672555,0.000001309782],"study_design_scores_gemma":[0.001273121,0.0003452046,0.1270847,0.0004188299,0.00007282586,5.315489e-7,0.000009303123,0.00008516893,0.8676682,0.000003619842,0.002301735,0.0007368506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964224,0.0002906712,0.0003115857,0.0006336125,0.0007284594,0.0009302059,0.0005583277,0.0001224708,0.000002268833],"genre_scores_gemma":[0.9967631,0.0002658524,0.00147277,0.0002669446,0.0003294167,0.0006898178,0.000009137226,0.0001599665,0.00004299737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1278217,"threshold_uncertainty_score":0.9996845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01387057748401758,"score_gpt":0.2371896526317104,"score_spread":0.2233190751476928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}