{"id":"W4387460339","doi":"10.1101/2023.10.05.560956","title":"ABI3 deletion in TgCRND8 mice is associated with reduced amyloid plaque pathology and altered glial response","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Canadian Institutes of Health Research; Alzheimer Society; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"Microglia; Genetically modified mouse; Gene knockin; Biology; Alzheimer's disease; Amyloid (mycology); Transgene; Pathology; Loss function; Amyloid precursor protein; Neuroscience; Genetics; Immunology; Gene; Phenotype; Medicine; Disease; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002833847,0.0009447244,0.000604576,0.001721766,0.0004573333,0.0005111368,0.0005398546,0.001076561,0.006834369],"category_scores_gemma":[0.0002325852,0.0004358515,0.0004931857,0.0005117143,0.000767699,0.0002354755,0.0004530412,0.001488273,0.001917681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004907456,"about_ca_system_score_gemma":0.0003014113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002084989,"about_ca_topic_score_gemma":0.003850929,"domain_scores_codex":[0.9995461,0.00004263806,0.00004831571,0.0001314848,0.0001523979,0.0000790405],"domain_scores_gemma":[0.9993748,0.00006109357,0.0003040803,0.0000495136,0.00004505677,0.0001655672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003765648,0.00005835223,0.0003646241,0.00003616254,0.00001231655,0.0002901424,0.00002323674,0.00004567435,0.9979404,0.0001119711,0.0001188332,0.0006218035],"study_design_scores_gemma":[0.0002718932,0.0003760714,0.0398018,0.00006693717,0.00009714189,0.003896814,0.0001930028,0.002131272,0.9467658,0.0005061339,0.005853966,0.00003910059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865956,0.0006652997,0.004495619,0.0003891625,0.00007658914,0.00003859001,0.004363239,0.0006041359,0.002771865],"genre_scores_gemma":[0.9663385,0.0006374069,0.009825591,0.0002451894,0.00004674681,0.0001467435,0.004290184,0.000619561,0.01785003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006834369,"threshold_uncertainty_score":0.02286321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01387057748401758,"score_gpt":0.2371896526317104,"score_spread":0.2233190751476928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}