{"id":"W4387460446","doi":"10.1101/2023.10.05.561142","title":"Retinoic Acid Boosts HIV-1 Replication in Macrophages <i>via</i> CCR5/SAMHD1-Dependent and mTOR-Modulated Mechanisms","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Caprion (Canada); Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"McGill University Health Centre; Canadian Institutes of Health Research; Canadian Foundation for AIDS Research; McGill University; Fondation du CHUM","keywords":"SAMHD1; Retinoic acid; Biology; PI3K/AKT/mTOR pathway; Viral replication; Downregulation and upregulation; Viral load; Immunology; Virology; Cell biology; Human immunodeficiency virus (HIV); Gene; Genetics; RNA; Signal transduction; Reverse transcriptase; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001361403,0.0002568036,0.0002078587,0.0002435749,0.0002314864,0.0003201047,0.0001591738,0.0002309181,0.009163486],"category_scores_gemma":[0.00009675352,0.00009601621,0.0001868303,0.000188374,0.0001497864,0.00015174,0.000195505,0.0004267301,0.003979067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001788833,"about_ca_system_score_gemma":0.000148594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004854431,"about_ca_topic_score_gemma":0.0006623915,"domain_scores_codex":[0.9999123,0.00001399564,0.000004148996,0.00001728439,0.00003372254,0.00001855928],"domain_scores_gemma":[0.9999756,0.000006380459,0.000003326496,0.000006011117,0.000003838352,0.000004884376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002180977,0.00001953309,0.0003267134,0.0001089919,0.000007396395,0.00008531522,0.00002588452,0.0001414323,0.9916733,0.0005829223,0.001923703,0.00488664],"study_design_scores_gemma":[0.0000310313,0.0001128225,0.005979992,0.00002024467,0.00001283165,0.0003214268,0.00004041833,0.001626658,0.9706708,0.0004097806,0.02076807,0.000005864761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8605134,0.008301294,0.03923498,0.003457338,0.0007391817,0.0001635422,0.02991314,0.004265561,0.05341154],"genre_scores_gemma":[0.9103548,0.003442955,0.02049504,0.0003315577,0.0001458041,0.0001040566,0.01101661,0.0004490813,0.05366009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009163486,"threshold_uncertainty_score":0.03065497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01558095888401983,"score_gpt":0.2376955893703512,"score_spread":0.2221146304863313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}