{"id":"W4387460817","doi":"10.1101/2023.10.05.557343","title":"Heterologous booster with a novel formulation containing glycosylated trimeric S protein is effective against Omicron","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Universidad Nacional de La Plata; Consejo Nacional de Investigaciones Científicas y Técnicas","keywords":"Heterologous; Vaccination; Booster (rocketry); Booster dose; Adjuvant; Virology; Vaccination schedule; Regimen; Immune system; Biology; Immunology; Medicine; Immunization; Gene; Genetics; Internal medicine; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001040872,0.0002856611,0.0003298463,0.0001059132,0.00006519861,0.0001590477,0.0002155736,0.0002299161,0.0006996678],"category_scores_gemma":[0.00007756102,0.00005966225,0.0001879728,0.00007799335,0.0001511814,0.0001634859,0.00007903713,0.0004357338,0.0001340368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001588077,"about_ca_system_score_gemma":0.0001796114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005244466,"about_ca_topic_score_gemma":0.000907516,"domain_scores_codex":[0.9999313,0.00001081258,0.000003842852,0.00001706737,0.0000206673,0.00001638219],"domain_scores_gemma":[0.9999558,0.000006834374,0.00001464367,0.00000450734,0.000006326028,0.00001193018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004933021,0.0004489349,0.0001904527,0.00007559288,0.000009035096,0.00002331953,0.00001434254,0.0001759694,0.9934529,0.00003070446,0.00005018447,0.005035347],"study_design_scores_gemma":[0.0001927304,0.02976197,0.005939575,0.00001597868,0.00006340149,0.0002368801,0.0000454037,0.001693016,0.9595022,0.00003319152,0.002507231,0.00000837792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980768,0.0005732259,0.000871632,0.00002585686,0.00003170954,0.00003251871,0.00004459794,0.00002035491,0.0003231459],"genre_scores_gemma":[0.9970583,0.000573414,0.001393021,0.00003728168,0.00002144796,0.00002300534,0.0001568468,0.000006499347,0.0007302285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006996678,"threshold_uncertainty_score":0.002340615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02831130464260727,"score_gpt":0.2790684361345094,"score_spread":0.2507571314919022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}