{"id":"W4387485265","doi":"10.1016/s2352-3018(23)00228-x","title":"HIV-1 drug resistance in people on dolutegravir-based antiretroviral therapy: a collaborative cohort analysis","year":2023,"lang":"en","type":"article","venue":"The Lancet HIV","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":128,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Hip and Knee Clinic; University of Calgary","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institute on Drug Abuse; Fogarty International Center; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism; National Institute of Allergy and Infectious Diseases; Medical Research Council; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; Ministerie van Volksgezondheid, Welzijn en Sport; Deutsches Zentrum für Infektionsforschung; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Styrelsen för Internationellt Utvecklingssamarbete; Gilead Sciences; Centre Hospitalier Universitaire de Bordeaux; National Institute of Diabetes and Digestive and Kidney Diseases; ViiV Healthcare; National Science Foundation","keywords":"Dolutegravir; Medicine; Cohort; Drug resistance; HIV drug resistance; Integrase inhibitor; Cohort study; Virology; Internal medicine; Antiretroviral therapy; Viral load; Human immunodeficiency virus (HIV); Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005751551,0.0002137965,0.0006894768,0.0003571328,0.0001229808,0.00003045758,0.0001746539,0.00004701738,0.00008864722],"category_scores_gemma":[0.00004806221,0.0001321102,0.0001268115,0.003881787,0.00006761074,0.00003697238,0.00002191787,0.0002025253,0.000600874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001694478,"about_ca_system_score_gemma":0.0001820923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002929783,"about_ca_topic_score_gemma":0.001149133,"domain_scores_codex":[0.9984363,0.0001677301,0.0002454462,0.0003467221,0.0004083892,0.0003954683],"domain_scores_gemma":[0.9990025,0.0002298606,0.00008769281,0.0005530534,0.00006268725,0.00006424959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001119031,0.0001545139,0.8904291,0.00001814474,0.0006646786,0.0001165119,0.003212665,0.0000877438,0.00008612376,0.0004586257,0.103489,0.0001638694],"study_design_scores_gemma":[0.004981351,0.00005797687,0.9533075,0.0001108419,0.0003482521,4.852719e-7,0.0005743824,0.0009594967,0.000756259,0.0001606207,0.0385123,0.0002305432],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9467315,0.0002780751,0.00002341453,0.04449976,0.00005477335,0.0006997752,0.000115183,0.0001787304,0.007418764],"genre_scores_gemma":[0.9219504,0.0003084958,0.0004918071,0.0008022833,0.000113008,0.0001680542,0.0006332811,0.00002460338,0.07550805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06808928,"threshold_uncertainty_score":0.7723219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01777257150136564,"score_gpt":0.2825013528993654,"score_spread":0.2647287813979998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}