{"id":"W4387491235","doi":"10.1016/j.cjcpc.2023.10.002","title":"Clinically Relevant Genetic Considerations for Patients With Tetralogy of Fallot","year":2023,"lang":"en","type":"article","venue":"CJC Pediatric and Congenital Heart Disease","topic":"Congenital Heart Disease Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mental Health Research Canada; Toronto General Hospital; University of Toronto; Centre for Addiction and Mental Health; University Health Network","funders":"Canadian Institutes of Health Research; W. Garfield Weston Foundation; Weston Family Foundation; McLaughlin Centre, University of Toronto","keywords":"Tetralogy of Fallot; Genetic testing; Medicine; Phenotype; Precision medicine; Population; Human genetics; Clinical Practice; Intensive care medicine; Bioinformatics; Internal medicine; Genetics; Heart disease; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007734726,0.0001916388,0.0004052283,0.0001771735,0.0001632661,0.00001466921,0.00003350257,0.00005634017,0.00004379985],"category_scores_gemma":[0.0008481075,0.0001589946,0.00012673,0.0003502528,0.0002287807,0.00006348047,0.00006427602,0.00008610324,0.00004179915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001471851,"about_ca_system_score_gemma":0.0004164277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000700778,"about_ca_topic_score_gemma":0.000009465855,"domain_scores_codex":[0.9985338,0.00003194918,0.0004579428,0.0003740945,0.0002632403,0.0003389947],"domain_scores_gemma":[0.9979814,0.0006688604,0.00004229401,0.0002495937,0.0005090993,0.0005487968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001291935,0.0003532061,0.9920052,0.0003391001,0.00008197848,0.00004470875,0.00007174214,5.95878e-7,0.000008085804,0.00005123601,0.004721924,0.001030313],"study_design_scores_gemma":[0.003448789,0.001206809,0.9927465,0.00001435062,0.0009752771,0.000005654297,0.00007671166,0.0001973807,0.000001630603,0.0009097846,0.000229484,0.000187567],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964287,0.0009540685,0.00001737768,0.0003739734,0.0001148431,0.001259576,0.0006271989,0.0001012843,0.0001229708],"genre_scores_gemma":[0.9979305,0.0001643386,0.0007343891,0.0003623556,0.0002116544,0.0001756683,0.00006051668,0.00003391727,0.0003266525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00449244,"threshold_uncertainty_score":0.6483614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02030675621217681,"score_gpt":0.2846756502184113,"score_spread":0.2643688940062345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}