{"id":"W4387492735","doi":"10.1523/eneuro.0079-23.2023","title":"Axonal Transport of Lysosomes Is Unaffected in Glucocerebrosidase-Inhibited iPSC-Derived Forebrain Neurons","year":2023,"lang":"en","type":"article","venue":"eNeuro","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Glycomics Network; Simon Fraser University; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Glucocerebrosidase; Synucleinopathies; Cell biology; Biology; Axoplasmic transport; Lysosome; Lysosomal storage disease; Induced pluripotent stem cell; Organelle; Intracellular; Biochemistry; Parkinson's disease; Alpha-synuclein; Enzyme; Internal medicine; Gene; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002278808,0.0002308368,0.000481932,0.0006608738,0.00005183693,0.000008630846,0.0001965897,0.0001303558,0.0005164632],"category_scores_gemma":[0.0004242282,0.0002206493,0.0001968337,0.002144605,0.0001547207,0.00009132703,0.00006717606,0.0003945352,0.0001157061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004757051,"about_ca_system_score_gemma":0.0001770915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000189135,"about_ca_topic_score_gemma":0.0001189477,"domain_scores_codex":[0.9976725,0.0001247375,0.0004367284,0.0004835727,0.0007109347,0.0005715413],"domain_scores_gemma":[0.9989337,0.0002658452,0.0000718724,0.0004219075,0.000107451,0.0001992111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007146455,0.0005534438,0.3195608,0.0004426503,0.00007555409,0.001368983,0.00143594,0.00007408601,0.6674979,0.0001099426,0.005143576,0.00302246],"study_design_scores_gemma":[0.003933038,0.0004841095,0.8646932,0.0001191173,0.00003335415,0.00003406338,0.0001477487,0.001844563,0.1273599,0.0000992303,0.001050177,0.0002014505],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947458,0.00006500026,0.00001579499,0.002701183,0.00008086769,0.0006721546,0.00006834669,0.0002171426,0.001433745],"genre_scores_gemma":[0.9976715,0.00007197687,0.00004910678,0.0007840437,0.00004606623,0.0000487828,0.0001648003,0.00007056999,0.001093103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5451325,"threshold_uncertainty_score":0.8997816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0262164656641066,"score_gpt":0.2970331268187291,"score_spread":0.2708166611546224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}