{"id":"W4387492735","doi":"10.1523/eneuro.0079-23.2023","title":"Axonal Transport of Lysosomes Is Unaffected in Glucocerebrosidase-Inhibited iPSC-Derived Forebrain Neurons","year":2023,"lang":"en","type":"article","venue":"eNeuro","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Glycomics Network; Simon Fraser University; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Glucocerebrosidase; Synucleinopathies; Cell biology; Biology; Axoplasmic transport; Lysosome; Lysosomal storage disease; Induced pluripotent stem cell; Organelle; Intracellular; Biochemistry; Parkinson's disease; Alpha-synuclein; Enzyme; Internal medicine; Gene; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002731091,0.000643047,0.0006980547,0.0003263343,0.0001857025,0.0005394028,0.0004776655,0.0006975423,0.001325122],"category_scores_gemma":[0.0001823026,0.0002405685,0.0005201086,0.0002018941,0.0004570176,0.000335083,0.0002663796,0.001262752,0.000612976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004658465,"about_ca_system_score_gemma":0.000361533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001726105,"about_ca_topic_score_gemma":0.001302839,"domain_scores_codex":[0.9996624,0.00002803898,0.00007701649,0.0000784044,0.00009768618,0.00005651524],"domain_scores_gemma":[0.9997186,0.00005340605,0.00007601758,0.00005003579,0.00004380749,0.00005802238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006882854,0.00002054697,0.00006430018,0.00003187673,0.000005940771,0.0001185319,0.00002096365,0.00005161223,0.9991181,0.00006971875,0.00001722518,0.0004122916],"study_design_scores_gemma":[0.000009830017,0.0001072833,0.001576746,0.000007129011,0.00001560271,0.0001527572,0.00002810585,0.0005625568,0.9966254,0.00002362979,0.0008866705,0.000004338735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907997,0.0008510292,0.003977839,0.0000932202,0.00006935615,0.00005715368,0.001761243,0.0001851306,0.002205292],"genre_scores_gemma":[0.9897242,0.0008722584,0.002680227,0.00005086225,0.000008428337,0.0001011723,0.001740874,0.00008421776,0.004737871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001726105,"threshold_uncertainty_score":0.004432976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0262164656641066,"score_gpt":0.2970331268187291,"score_spread":0.2708166611546224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}