{"id":"W4387494856","doi":"10.1016/j.crmeth.2023.100602","title":"Insulin C-peptide secretion on-a-chip to measure the dynamics of secretion and metabolism from individual islets","year":2023,"lang":"en","type":"article","venue":"Cell Reports Methods","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Breakthrough T1D Canada; Canadian Institutes of Health Research","keywords":"Islet; Secretion; Insulin; Internal medicine; Endocrinology; Biology; Carbohydrate metabolism; Metabolism; Chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002808626,0.0001736736,0.0004238351,0.0002007719,0.00008564604,0.00002279204,0.00005768323,0.0001417226,0.0001177211],"category_scores_gemma":[0.00221886,0.0001212048,0.0001013808,0.0005094942,0.00007485477,0.00004129548,0.00006645409,0.0002309733,0.00001622642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003621243,"about_ca_system_score_gemma":0.00008725071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001095725,"about_ca_topic_score_gemma":0.000003965868,"domain_scores_codex":[0.998105,0.0003887733,0.0004834766,0.000362824,0.0004584844,0.000201405],"domain_scores_gemma":[0.9982027,0.0007088796,0.0002616669,0.0005155621,0.0001337011,0.0001775225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006336562,0.0003048444,0.03460661,0.0003056738,0.0005867354,0.0002766783,0.006606726,0.0004121544,0.698933,0.001657038,0.006972966,0.2487039],"study_design_scores_gemma":[0.001879169,0.0004155451,0.7182857,0.0003661146,0.001269326,0.00009425818,0.002414325,0.008182592,0.2288164,0.00944203,0.02836462,0.0004699871],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771594,0.000602027,0.01124516,0.0008977664,0.0006977509,0.0004736535,0.00002820608,0.0001071494,0.008788817],"genre_scores_gemma":[0.9627291,0.0001179122,0.03359291,0.0009184092,0.000243829,0.00004865466,0.0003823613,0.00003768357,0.001929124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.683679,"threshold_uncertainty_score":0.4942587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03785079264642915,"score_gpt":0.3155314988844284,"score_spread":0.2776807062379993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}