{"id":"W4387496847","doi":"10.1016/j.euroneuro.2023.08.224","title":"W34. DNA METHYLATION, GENE EXPRESSION, AND RESPONSE TO LITHIUM IN BIPOLAR DISORDER: A STUDY FROM IPS CELLS DERIVED INTO NEURONS","year":2023,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; Dalhousie University; McGill University","funders":"","keywords":"Bipolar disorder; Wnt signaling pathway; DNA methylation; Epigenetics; Mood stabilizer; Mood; Lithium (medication); Mood disorders; Methylation; Genetics; Biology; Bioinformatics; Gene expression; Gene; Medicine; Internal medicine; Clinical psychology; Psychiatry; Anxiety","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001346324,0.0001753223,0.0002816262,0.000220369,0.0001916006,0.0002517073,0.0001701285,0.0003293529,0.001906041],"category_scores_gemma":[0.00008982535,0.0001297447,0.0003769993,0.0001567589,0.0001968255,0.0001563044,0.0001412073,0.0006099194,0.0003536165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001715256,"about_ca_system_score_gemma":0.0001886055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001428587,"about_ca_topic_score_gemma":0.001712733,"domain_scores_codex":[0.9999055,0.00001018042,0.000009976149,0.00002192457,0.00002777606,0.00002464613],"domain_scores_gemma":[0.9999677,0.000006936987,0.000009029375,0.000004091944,0.000004513553,0.00000768854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002021793,0.00005708507,0.0003626559,0.00002438186,0.00001138177,0.00006055853,0.00002883029,0.00004921135,0.9973615,0.0000631591,0.00005415205,0.001724943],"study_design_scores_gemma":[0.0001022532,0.001279327,0.03256958,0.00001763208,0.0001538653,0.0006167425,0.0001781155,0.001407914,0.9592075,0.0001230476,0.004326939,0.0000170697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959275,0.0007432395,0.001237854,0.00006857264,0.00003357534,0.00002864569,0.0006355442,0.00003135773,0.001293679],"genre_scores_gemma":[0.9934533,0.0006389169,0.000762707,0.00006965135,0.000007924816,0.00005825607,0.00088046,0.00002655267,0.00410225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001906041,"threshold_uncertainty_score":0.006376326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01750643387860175,"score_gpt":0.3032690565263931,"score_spread":0.2857626226477914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}