{"id":"W4387501723","doi":"10.26434/chemrxiv-2023-jdhxk","title":"Metal Ions Turn on a Stereoselective Nonenzymatic Reduction of Keto Acids by the Coenzyme NADH","year":2023,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Origins and Evolution of Life","field":"Physics and Astronomy","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Volkswagen Foundation; Université de Strasbourg; Deutsche Forschungsgemeinschaft; Equipex","keywords":"Cofactor; NAD+ kinase; Chemistry; Stereoselectivity; Enzyme; Metabolism; Redox; Stereochemistry; Molecule; Nicotinamide adenine dinucleotide; Metal; Nicotinamide; Chirality (physics); Coenzyme A; Biochemistry; Catalysis; Organic chemistry; Reductase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001686897,0.000367796,0.0003414578,0.000159556,0.0003463756,0.0007223726,0.0005224479,0.0004305005,0.002817726],"category_scores_gemma":[0.0003914791,0.0002786264,0.0003785865,0.0001383238,0.0004462118,0.0005369334,0.0003181678,0.0004219468,0.000711352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004036868,"about_ca_system_score_gemma":0.0002651375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001221311,"about_ca_topic_score_gemma":0.001036075,"domain_scores_codex":[0.9998927,0.00001204101,0.000004904939,0.0000384947,0.00002329457,0.00002860727],"domain_scores_gemma":[0.999934,0.00002315062,0.00001360091,0.00001026308,0.000009448976,0.000009601108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001290087,0.0003554787,0.01254643,0.001544859,0.0003292843,0.001777402,0.0006599703,0.05551824,0.7474449,0.1302489,0.008836414,0.0394479],"study_design_scores_gemma":[0.0003097662,0.000565576,0.00386533,0.00006176753,0.0001526123,0.000767651,0.0003561503,0.2069624,0.7182434,0.04419943,0.02441533,0.0001005758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9436174,0.001599305,0.02430625,0.0008742948,0.0003523453,0.00004154714,0.0004052621,0.0006687536,0.02813492],"genre_scores_gemma":[0.9931597,0.0006038394,0.003299706,0.00008814914,0.0000150013,0.00001039607,0.0001048466,0.00005201002,0.002666303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002817726,"threshold_uncertainty_score":0.009426236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02860452803324967,"score_gpt":0.275376261041639,"score_spread":0.2467717330083894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}