{"id":"W4387502262","doi":"10.1016/j.euroneuro.2023.08.216","title":"W26. POLYGENIC RISK SCORE ANALYSIS OF ANTIDEPRESSANT TREATMENT RESPONSE: RESULTS FROM THE CAN-BIND-1 COHORT","year":2023,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Major depressive disorder; Antidepressant; Aripiprazole; Medicine; Escitalopram; Bipolar disorder; Internal medicine; Psychiatry; Population; Polygenic risk score; Cohort; Depression (economics); Schizophrenia (object-oriented programming); Oncology; Mood; Single-nucleotide polymorphism; Genotype; Anxiety; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001861292,0.001208535,0.0009992023,0.0008213655,0.0009976175,0.001196875,0.001124561,0.001226567,0.00973804],"category_scores_gemma":[0.004135295,0.0005773709,0.002012614,0.001662628,0.0003661026,0.0005806949,0.000913368,0.001328236,0.001253502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000260695,"about_ca_system_score_gemma":0.0005439122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02286067,"about_ca_topic_score_gemma":0.01602797,"domain_scores_codex":[0.9985727,0.000451114,0.00007090528,0.0005681678,0.000129697,0.0002072683],"domain_scores_gemma":[0.997724,0.0005694482,0.0006001165,0.0006204495,0.0001848673,0.0003010894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01095337,0.0003198423,0.9374965,0.0001892135,0.008078634,0.0009265296,0.0003019895,0.001574191,0.005250909,0.001297447,0.02229082,0.01132045],"study_design_scores_gemma":[0.0006574347,0.0003312859,0.9874647,0.00005652024,0.0025965,0.0006547215,0.0001549701,0.002336961,0.000557084,0.0009284061,0.004214705,0.00004687632],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9463845,0.001252179,0.003427437,0.0007670075,0.0002910175,0.00005761137,0.04415285,0.0002124302,0.003454928],"genre_scores_gemma":[0.9755591,0.0002609646,0.001381946,0.0003023416,0.0001503006,0.0001254455,0.01643258,0.0001602698,0.005627105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02286067,"threshold_uncertainty_score":0.04545522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02630728587763765,"score_gpt":0.2966746841589524,"score_spread":0.2703673982813147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}