{"id":"W4387502262","doi":"10.1016/j.euroneuro.2023.08.216","title":"W26. POLYGENIC RISK SCORE ANALYSIS OF ANTIDEPRESSANT TREATMENT RESPONSE: RESULTS FROM THE CAN-BIND-1 COHORT","year":2023,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Major depressive disorder; Antidepressant; Aripiprazole; Medicine; Escitalopram; Bipolar disorder; Internal medicine; Psychiatry; Population; Polygenic risk score; Cohort; Depression (economics); Schizophrenia (object-oriented programming); Oncology; Mood; Single-nucleotide polymorphism; Genotype; Anxiety; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.002475123,0.0003573144,0.0004717393,0.000236486,0.0003089166,0.00002422714,0.0007464715,0.00005674546,0.001099494],"category_scores_gemma":[0.0004482213,0.000273808,0.0002739856,0.002067003,0.0005497765,0.00007872552,0.0004258846,0.0004110536,0.001463919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002051561,"about_ca_system_score_gemma":0.00003171167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002048073,"about_ca_topic_score_gemma":0.0002219698,"domain_scores_codex":[0.9909667,0.005752055,0.000803168,0.001326035,0.0004719998,0.0006800929],"domain_scores_gemma":[0.9958696,0.002173685,0.0005330031,0.001159843,0.00001255451,0.0002513397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002305207,0.000230702,0.8234734,0.000001646054,0.001088772,0.0006417439,0.00192102,0.01266865,0.1424187,7.159123e-7,0.006061289,0.00918818],"study_design_scores_gemma":[0.002160096,0.0002701088,0.9722661,0.000005582498,0.001258039,0.000003843852,0.00006382314,0.001894709,0.000613025,0.000005206999,0.02123581,0.0002236536],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924073,0.00005726318,0.00002622745,0.001746426,0.000480074,0.000738801,0.001128108,0.0002200838,0.003195696],"genre_scores_gemma":[0.9951339,0.001901196,0.00003479836,0.001752103,0.0001170495,0.00003036354,0.0001201145,0.0001043072,0.0008061422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1487927,"threshold_uncertainty_score":0.9999714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02630728587763765,"score_gpt":0.2966746841589524,"score_spread":0.2703673982813147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}