{"id":"W4387502413","doi":"10.1016/j.euroneuro.2023.08.438","title":"F50. INTEGRATIVE ANALYSIS OF TRANSCRIPTOME AND PROTEOME-WIDE ASSOCIATION STUDY IDENTIFIES NOVEL GENES IMPLICATED IN TOURETTE'S SYNDROME","year":2023,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Genome-wide association study; Transcriptome; Biology; Gene; Proteome; Computational biology; Genetic association; Genetics; Gene expression; Genome; Imputation (statistics); Single-nucleotide polymorphism; Genotype; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000979055,0.0003879878,0.0008555092,0.00210919,0.0000842251,0.00004227648,0.0005231631,0.00009414107,0.0004130967],"category_scores_gemma":[0.0002195496,0.000385297,0.0002052832,0.005014864,0.0001651138,0.00014021,0.0001315743,0.0005610978,0.0001740081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008478659,"about_ca_system_score_gemma":0.00001898448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000149124,"about_ca_topic_score_gemma":0.0001730386,"domain_scores_codex":[0.9950663,0.002082668,0.0009084266,0.001010414,0.0003020735,0.0006301149],"domain_scores_gemma":[0.9980503,0.0007219942,0.0005372224,0.0004275589,0.0001462462,0.0001166738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004944017,0.001589475,0.6052672,0.00002687395,0.00386104,0.001110981,0.01222522,0.0002984556,0.3708148,0.00005782918,0.003375129,0.0008785789],"study_design_scores_gemma":[0.004049382,0.0005645931,0.9912807,0.000008783234,0.0008209402,0.000008985745,0.002327473,0.0001224953,0.0001157263,0.00003041893,0.0003777916,0.0002927574],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933261,0.0001599281,0.00005821997,0.001453704,0.00120808,0.001440932,0.00008012825,0.0003345167,0.001938446],"genre_scores_gemma":[0.9978514,0.00007436518,0.00001496086,0.0006308322,0.00004139334,0.0001447125,0.00003873738,0.0001168101,0.001086786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3860134,"threshold_uncertainty_score":0.9998599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01814708094560103,"score_gpt":0.3224915044614609,"score_spread":0.3043444235158598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}