{"id":"W4387515915","doi":"10.1101/pdb.prot108340","title":"Validating Single-Guide RNA for<i>Aedes aegypti</i>Gene Editing","year":2023,"lang":"en","type":"article","venue":"Cold Spring Harbor Protocols","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Aedes aegypti; Computational biology; RNA editing; Gene; Biology; RNA; Computer science; Genetics; Ecology; Larva","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004843182,0.0002211932,0.0001932141,0.00007715318,0.0001723175,0.00009908469,0.000275687,0.0001354502,0.000006431572],"category_scores_gemma":[0.0004038069,0.0002473275,0.0001406852,0.0001913813,0.00003057133,0.000006544071,0.0001948953,0.00009518117,0.00001970168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000300592,"about_ca_system_score_gemma":0.00005174645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006906672,"about_ca_topic_score_gemma":0.000004377635,"domain_scores_codex":[0.998473,0.00002396656,0.0003473008,0.000466403,0.0001676445,0.0005216724],"domain_scores_gemma":[0.9991937,0.00004008411,0.0001001188,0.0004444511,0.0001084836,0.000113223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001801102,0.00002275554,0.0005551476,0.0001407208,0.00003118804,0.000003841576,0.00001483893,0.00131249,0.9953337,0.0002868621,0.001475922,0.0008045802],"study_design_scores_gemma":[0.0005852644,0.0001704962,0.0005043803,0.0001035718,0.00001055487,8.600879e-7,0.0000168831,0.0009393047,0.8480822,0.00001215886,0.1493253,0.0002489653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6202908,0.0004348845,0.2677322,0.0004492287,0.001164703,0.1058664,0.0001224849,0.001100695,0.00283866],"genre_scores_gemma":[0.8738565,0.00001314578,0.02602957,0.000175053,0.002746238,0.09589855,0.00003028727,0.0001792975,0.001071298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2535658,"threshold_uncertainty_score":0.9999979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02819755587767136,"score_gpt":0.3395659930643332,"score_spread":0.3113684371866618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}