{"id":"W4387516303","doi":"10.1111/cts.13623","title":"MIJ821 (onfasprodil) in healthy volunteers: First‐in‐human, randomized, placebo‐controlled study (single ascending dose and repeated intravenous dose)","year":2023,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Novartis Institutes for BioMedical Research","keywords":"Medicine; Placebo; Pharmacokinetics; Tolerability; Adverse effect; Anesthesia; Single Center; Intravenous Infusions; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002287013,0.00235378,0.003765115,0.0005030914,0.0006774218,0.0009507381,0.00108475,0.002085266,0.004155438],"category_scores_gemma":[0.001581733,0.001370683,0.0009379618,0.0004522462,0.001423964,0.001079719,0.0003424999,0.002086403,0.0008547649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005311787,"about_ca_system_score_gemma":0.001214811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006237964,"about_ca_topic_score_gemma":0.00162892,"domain_scores_codex":[0.9989451,0.0005174156,0.00007387988,0.0002111542,0.00009985182,0.0001526193],"domain_scores_gemma":[0.9991127,0.0001635849,0.0002200801,0.00009882336,0.00009546498,0.0003092458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9214263,0.02930536,0.0008639268,0.0006531239,0.0005941761,0.00009361454,0.00006698987,0.000206854,0.03084051,0.00006982737,0.0007465893,0.01513277],"study_design_scores_gemma":[0.5906671,0.3992063,0.005221609,0.00002136009,0.0004576067,0.00006960679,0.00002583156,0.0004497403,0.002972538,0.00005161232,0.0008300039,0.00002669382],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905707,0.002351952,0.0009960643,0.0002414242,0.0003609671,0.00384184,0.0005083633,0.0001647593,0.0009638961],"genre_scores_gemma":[0.9845189,0.001982654,0.002806826,0.0008703519,0.0008816819,0.00539638,0.0005685191,0.00004167323,0.002933091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004155438,"threshold_uncertainty_score":0.01390129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07457057673427728,"score_gpt":0.4081947047563376,"score_spread":0.3336241280220603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}