{"id":"W4387516303","doi":"10.1111/cts.13623","title":"MIJ821 (onfasprodil) in healthy volunteers: First‐in‐human, randomized, placebo‐controlled study (single ascending dose and repeated intravenous dose)","year":2023,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Novartis Institutes for BioMedical Research","keywords":"Medicine; Placebo; Pharmacokinetics; Tolerability; Adverse effect; Anesthesia; Single Center; Intravenous Infusions; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006097306,0.0001457451,0.0007682709,0.0003653737,0.0002581857,0.00005571851,0.00009221407,0.00006770006,0.00003351706],"category_scores_gemma":[0.001121307,0.0001027917,0.00009313857,0.0008523367,0.001054328,0.0001486926,0.0000383494,0.0003049766,0.00001069848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003515859,"about_ca_system_score_gemma":0.0002234956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003342883,"about_ca_topic_score_gemma":0.001254347,"domain_scores_codex":[0.997278,0.0002554333,0.0008350203,0.0006298381,0.0005539653,0.0004476842],"domain_scores_gemma":[0.9975818,0.001777833,0.00006268157,0.0001560347,0.00007625689,0.0003454233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1300224,0.002028364,0.8575462,0.00005296426,0.00007135708,0.0002817747,0.001276391,0.00004730768,0.0001005667,0.0006335989,0.000008377899,0.007930673],"study_design_scores_gemma":[0.2903159,0.001227151,0.7015233,0.0000933492,0.00003593379,0.000009508861,0.0001598895,0.005510351,0.000004052625,0.0010257,0.00001471918,0.00008011492],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992153,0.0003519378,0.00001462997,0.004260158,0.00007595655,0.002447652,0.000004087022,0.00003691524,0.0006556585],"genre_scores_gemma":[0.9991006,0.0003225638,0.0001629114,0.00009323821,0.00006027825,0.0001219329,0.00001158713,0.000007598162,0.0001192372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1602935,"threshold_uncertainty_score":0.4191723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07457057673427728,"score_gpt":0.4081947047563376,"score_spread":0.3336241280220603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}