{"id":"W4387520439","doi":"10.1016/j.jbc.2023.105341","title":"Reversible and irreversible inhibitors of coronavirus Nsp15 endoribonuclease","year":2023,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Toronto; University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; Li Ka Shing Institute of Virology, University of Alberta; University of California, San Francisco; Canadian Institutes of Health Research; Alliance de recherche numérique du Canada; University of British Columbia; University of Alberta","keywords":"Coronavirus; Endoribonuclease; RNA; Virology; Protease; RNA-dependent RNA polymerase; Biology; Polymerase; Enzyme; Medicine; Biochemistry; Disease; Gene; Coronavirus disease 2019 (COVID-19); RNase P; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002533392,0.0005625506,0.0002710543,0.0002758782,0.0001547128,0.0002194893,0.0003212855,0.0002592102,0.001387425],"category_scores_gemma":[0.0001684859,0.000158094,0.0003446374,0.0002155355,0.0001722135,0.0002155214,0.0002335443,0.0005242249,0.0002798204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002909847,"about_ca_system_score_gemma":0.0003199125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006745855,"about_ca_topic_score_gemma":0.00227491,"domain_scores_codex":[0.9998251,0.00002764856,0.00001682891,0.00003409514,0.00006220155,0.00003419998],"domain_scores_gemma":[0.9999299,0.00001650152,0.00001852125,0.000008968164,0.00001225599,0.00001383232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001710809,0.000195791,0.0004413523,0.0002526266,0.00004337226,0.000133947,0.00002267728,0.0008718952,0.9816605,0.0004659992,0.0002331184,0.01550762],"study_design_scores_gemma":[0.000120353,0.003034039,0.002595133,0.00002781163,0.00005957147,0.000475109,0.00002477622,0.001298973,0.9841667,0.0001138969,0.00806997,0.00001353403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9476699,0.02363686,0.01238337,0.0002626623,0.00009621721,0.0004389061,0.001238952,0.0002254489,0.01404769],"genre_scores_gemma":[0.978837,0.009435163,0.00640789,0.000137149,0.00001756599,0.0001193504,0.0008912045,0.00001811554,0.004136541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001387425,"threshold_uncertainty_score":0.004641354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07699171354383677,"score_gpt":0.3479034499958541,"score_spread":0.2709117364520173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}