{"id":"W4387526346","doi":"10.1126/scitranslmed.adg1485","title":"Regeneration of neuromuscular synapses after acute and chronic denervation by inhibiting the gerozyme 15-prostaglandin dehydrogenase","year":2023,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute; National Institute on Aging; National Institutes of Health; California Institute for Regenerative Medicine; Milky Way Research Foundation; Donald E. and Delia B. Baxter Foundation; Canadian Institutes of Health Research; Li Ka Shing Foundation","keywords":"Denervation; Neuromuscular junction; Regeneration (biology); Sciatic nerve; Prostaglandin E2; Medicine; Prostaglandin; Skeletal muscle; Internal medicine; Endocrinology; Biology; Neuroscience; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003823439,0.00007037802,0.00007033085,0.00005397502,0.0001577591,0.000005671147,0.00008749292,0.00003309013,0.00001536839],"category_scores_gemma":[0.00006637357,0.0000477362,0.00001959704,0.0003109865,0.0006961034,0.00001370928,0.00002003934,0.00004139544,0.000001166456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003629306,"about_ca_system_score_gemma":0.00007847719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000930596,"about_ca_topic_score_gemma":0.00002773683,"domain_scores_codex":[0.9992673,0.00003336628,0.0001452161,0.0002198819,0.0002005701,0.0001336686],"domain_scores_gemma":[0.9997305,0.0000250739,0.000048395,0.0001020099,0.00005852996,0.00003549042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003843181,0.000005092714,0.001374142,0.00001058691,0.00000876637,5.534424e-7,0.0001017538,0.0002943807,0.9969579,0.000204033,0.0002337589,0.0007705734],"study_design_scores_gemma":[0.0009995201,0.0004342289,0.04879974,0.00004238335,0.00004439177,0.00001001581,0.00009653903,0.006446795,0.9409325,0.001367467,0.0006781906,0.0001482199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942461,0.001313852,0.0008971734,0.003296698,0.00005795687,0.0001234817,0.00001564359,0.000007425242,0.00004168834],"genre_scores_gemma":[0.9990893,0.0002477631,0.00003465056,0.0002667679,0.00009731882,0.00002127958,0.0002077358,0.000004616753,0.00003058443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05602542,"threshold_uncertainty_score":0.2564822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009769347998128742,"score_gpt":0.2609994195334046,"score_spread":0.2512300715352759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}