{"id":"W4387526478","doi":"10.21203/rs.3.rs-3414434/v1","title":"The Regulation of Plasma Gelsolin by Dna Methylation in Ovarian Cancer Chemo-resistance","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Toronto","funders":"Génome Québec; McGill University; Canadian Institutes of Health Research; University of Ottawa","keywords":"Gelsolin; Ovarian cancer; Cancer research; DNA methylation; Biology; Cisplatin; Cancer; Methylation; Molecular biology; Gene expression; Gene; Cell biology; Chemotherapy; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008383168,0.0001542224,0.0001359801,0.0001964911,0.00009807929,0.0001891542,0.00009454543,0.0001752137,0.0009150892],"category_scores_gemma":[0.0001536422,0.0001067582,0.0001421002,0.0001175042,0.000132083,0.0001358476,0.0001395116,0.0002509436,0.0001262513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002511135,"about_ca_system_score_gemma":0.0001226878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005356047,"about_ca_topic_score_gemma":0.0007253537,"domain_scores_codex":[0.9999348,0.000009642335,0.00000510616,0.00001921605,0.00001732486,0.00001394601],"domain_scores_gemma":[0.9999231,0.00001186769,0.00003474242,0.00000566017,0.00001266717,0.00001199111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001933591,0.00001282531,0.003206744,0.00008206649,0.00001242197,0.00005316651,0.00003841405,0.0001035666,0.9925296,0.00007218663,0.00007387537,0.003621772],"study_design_scores_gemma":[0.0000281076,0.0003481279,0.1140121,0.00002336744,0.00005938808,0.0006564875,0.0001085223,0.001796889,0.8768967,0.0002022227,0.005853464,0.00001456502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925686,0.004652236,0.001180215,0.0001340199,0.00001904919,0.00002046872,0.0003666926,0.00006749391,0.0009911745],"genre_scores_gemma":[0.9977071,0.0008395096,0.0003961421,0.00002829514,0.000004056771,0.00001409452,0.0001968913,0.000006866408,0.0008069216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009150892,"threshold_uncertainty_score":0.003061235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05105749027464815,"score_gpt":0.3871517426897128,"score_spread":0.3360942524150646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}