{"id":"W4387529062","doi":"10.1161/hyp.80.suppl_1.032","title":"Abstract 032: Downregulation Of Trpm7 Is Associated With Inflammation And Fibrosis In Aldosterone-induced Hypertension","year":2023,"lang":"en","type":"article","venue":"Hypertension","topic":"Magnesium in Health and Disease","field":"Nursing","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Aldosterone; Endocrinology; Internal medicine; Mineralocorticoid receptor; Mineralocorticoid; TRPM7; SGK1; Downregulation and upregulation; Eplerenone; Chemistry; Homeostasis; Epithelial sodium channel; Fibrosis; Cardiac fibrosis; Medicine; Receptor; Sodium; Glucocorticoid; Transient receptor potential channel; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008635879,0.0002835155,0.0003194876,0.0002078026,0.0001361325,0.0002373258,0.0001387455,0.0003721582,0.004042368],"category_scores_gemma":[0.00007850875,0.000153176,0.0003413899,0.0001361173,0.000244685,0.0001771991,0.0001557079,0.0008064167,0.0008830169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001106437,"about_ca_system_score_gemma":0.00009968895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002172791,"about_ca_topic_score_gemma":0.0002226402,"domain_scores_codex":[0.999895,0.0000113104,0.00001137906,0.00002813246,0.00003135875,0.0000228717],"domain_scores_gemma":[0.9998643,0.000009054733,0.00004944147,0.000007589736,0.00001556612,0.00005388669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004029176,0.00002506636,0.0004584731,0.00005539439,0.000006963226,0.0001512383,0.000009316386,0.000007335545,0.9980534,0.00002293969,0.0001121339,0.0006947043],"study_design_scores_gemma":[0.0001626508,0.001310026,0.09717295,0.00004128118,0.0001353595,0.004967395,0.0002058614,0.0006849892,0.887619,0.0002520128,0.00742914,0.00001931117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9929559,0.002053736,0.002301711,0.0003566228,0.0001263728,0.00001885707,0.001224617,0.0001165371,0.0008455576],"genre_scores_gemma":[0.9902841,0.001294818,0.0009343326,0.0002880735,0.00007043761,0.00004798767,0.001243662,0.00004730988,0.005789097],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.004042368,"threshold_uncertainty_score":0.01352304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03957182837570828,"score_gpt":0.2590709870153712,"score_spread":0.2194991586396629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}