{"id":"W4387529083","doi":"10.1128/mbio.01510-23","title":"Functional diversification despite structural congruence in the HipBST toxin-antitoxin system of <i>Legionella pneumophila</i>","year":2023,"lang":"en","type":"article","venue":"mBio","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; National Institutes of Health; U.S. Department of Health and Human Services; Government of Canada; Government of Ontario; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada","keywords":"Antitoxin; Legionella pneumophila; Biology; Microbiology; Toxin; Pathogen; Genome; Genetics; Computational biology; Bacteria; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002854904,0.00008399329,0.00008744105,0.00006639671,0.00009134445,0.00002027434,0.0002583329,0.00008100673,0.000003065982],"category_scores_gemma":[0.00003309679,0.00006275874,0.0000570778,0.0003064792,0.000110355,0.000005192189,0.00008073039,0.00008700997,0.00004666516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001752472,"about_ca_system_score_gemma":0.00004303797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001518874,"about_ca_topic_score_gemma":0.00003545604,"domain_scores_codex":[0.9991202,0.00007447982,0.00016181,0.0002221046,0.0002289117,0.0001925173],"domain_scores_gemma":[0.9995428,0.000027302,0.00005818532,0.0002703677,0.00007067644,0.00003064415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008391049,0.00001880213,0.05189344,0.00006256615,0.00001932987,0.00001525211,0.0001758997,0.0001806435,0.9401627,0.001459237,0.005630022,0.0002982034],"study_design_scores_gemma":[0.001287654,0.0002296436,0.5706905,0.00006600127,0.00002017966,0.00006964333,0.002837775,0.001064878,0.4168597,0.0002135792,0.006330969,0.0003295886],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983757,0.00009881355,0.00002824863,0.0006013555,0.0001973671,0.0001601288,0.0000227266,0.00001258061,0.0005031446],"genre_scores_gemma":[0.9991018,0.00005667224,0.00001266606,0.00009648663,0.0001467669,0.00001417312,0.0001607988,0.000007311878,0.0004033862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.523303,"threshold_uncertainty_score":0.2559227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02256837000409202,"score_gpt":0.2582316419250814,"score_spread":0.2356632719209893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}