{"id":"W4387529083","doi":"10.1128/mbio.01510-23","title":"Functional diversification despite structural congruence in the HipBST toxin-antitoxin system of <i>Legionella pneumophila</i>","year":2023,"lang":"en","type":"article","venue":"mBio","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; National Institutes of Health; U.S. Department of Health and Human Services; Government of Canada; Government of Ontario; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada","keywords":"Antitoxin; Legionella pneumophila; Biology; Microbiology; Toxin; Pathogen; Genome; Genetics; Computational biology; Bacteria; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001214247,0.0002143596,0.0001706318,0.0003569975,0.0001635465,0.0003903249,0.000169489,0.000237867,0.000774089],"category_scores_gemma":[0.0002015004,0.0001062479,0.000234026,0.0002920019,0.0002339644,0.0001767681,0.0003293504,0.0002934143,0.0003635818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000254848,"about_ca_system_score_gemma":0.0001563117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006030578,"about_ca_topic_score_gemma":0.0004329673,"domain_scores_codex":[0.9998553,0.00001838142,0.00001604734,0.00003494688,0.0000398857,0.00003531067],"domain_scores_gemma":[0.9997602,0.0000268045,0.00007680104,0.00003503214,0.00003850289,0.00006269807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005669376,0.000009492983,0.003725884,0.00001832429,0.000007919877,0.00008530788,0.0000315969,0.00002716468,0.9948018,0.00004139122,0.0000179418,0.001176518],"study_design_scores_gemma":[0.0000227351,0.0006195304,0.4035856,0.00001685982,0.00007781156,0.003724569,0.0004739345,0.001273085,0.5868051,0.0001914023,0.003189912,0.00001943266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989589,0.0001508927,0.0003062384,0.00002224943,0.000002340176,0.000003277097,0.000133438,0.00001750543,0.0004051729],"genre_scores_gemma":[0.9986551,0.00005379725,0.0004204338,0.00002463076,0.000001873612,0.00000488935,0.0004469893,0.000008707877,0.0003835524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000774089,"threshold_uncertainty_score":0.002589583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02256837000409202,"score_gpt":0.2582316419250814,"score_spread":0.2356632719209893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}