{"id":"W4387529303","doi":"10.1158/0008-5472.can-23-2545","title":"The BRD4–NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto","funders":"Daiichi Sankyo Europe; National Institutes of Health; National Cancer Institute; Strong; Samuel Waxman Cancer Research Foundation; Garron Family Cancer Centre; National Heart, Lung, and Blood Institute; Dana-Farber Cancer Institute; Amgen; Fondation Bertarelli; Cancer Prevention and Research Institute of Texas; Alex's Lemonade Stand Foundation for Childhood Cancer; Dana-Farber/Harvard Cancer Center; AstraZeneca","keywords":"Cancer research; Bromodomain; CD44; Biology; Epigenetics; BMI1; Transcriptome; BRD4; Pathology; Cell; Medicine; Stem cell; Cell biology; Gene expression; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001384216,0.0001735249,0.0001709862,0.0002754217,0.0001597071,0.0003003445,0.0001923586,0.0002821535,0.001353894],"category_scores_gemma":[0.0001524023,0.0001693248,0.0002330021,0.0001425598,0.0002306131,0.0001548571,0.0002344363,0.0005969071,0.0004305628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00053751,"about_ca_system_score_gemma":0.0002356603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001511886,"about_ca_topic_score_gemma":0.002916305,"domain_scores_codex":[0.9997787,0.00001767559,0.00002841006,0.0000560348,0.00008204659,0.00003729179],"domain_scores_gemma":[0.9998608,0.0000207414,0.00003783125,0.00002594706,0.00001516257,0.00003959187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005299555,0.00003010601,0.0004305522,0.00001235524,0.00000331451,0.00005111106,0.00002587126,0.00008987986,0.9982888,0.0001904967,0.00007325644,0.0007512044],"study_design_scores_gemma":[0.00002160938,0.0002443336,0.007260278,0.000006065399,0.00001648772,0.0005187675,0.00006810079,0.003208699,0.9829099,0.00007237762,0.005667605,0.000005793112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993766,0.0002872202,0.002806315,0.00008769944,0.00002152525,0.00005213636,0.001056697,0.0001338985,0.001788473],"genre_scores_gemma":[0.9929512,0.0001913662,0.00183152,0.00003820147,0.000002763505,0.00003778534,0.001089932,0.0000276817,0.003829582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001511886,"threshold_uncertainty_score":0.004529238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04429623205560875,"score_gpt":0.358375543595772,"score_spread":0.3140793115401632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}