{"id":"W4387529303","doi":"10.1158/0008-5472.can-23-2545","title":"The BRD4–NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto","funders":"Daiichi Sankyo Europe; National Institutes of Health; National Cancer Institute; Strong; Samuel Waxman Cancer Research Foundation; Garron Family Cancer Centre; National Heart, Lung, and Blood Institute; Dana-Farber Cancer Institute; Amgen; Fondation Bertarelli; Cancer Prevention and Research Institute of Texas; Alex's Lemonade Stand Foundation for Childhood Cancer; Dana-Farber/Harvard Cancer Center; AstraZeneca","keywords":"Cancer research; Bromodomain; CD44; Biology; Epigenetics; BMI1; Transcriptome; BRD4; Pathology; Cell; Medicine; Stem cell; Cell biology; Gene expression; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006645805,0.00005896981,0.00006719147,0.0000709204,0.0002227871,0.00002245807,0.0002030491,0.00006970659,0.00002996903],"category_scores_gemma":[0.00007443082,0.00004127703,0.00004701078,0.0003035834,0.0001578135,0.000005297791,0.00007835929,0.0001030961,0.00002389469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002221063,"about_ca_system_score_gemma":0.0001523553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001576122,"about_ca_topic_score_gemma":0.0001101063,"domain_scores_codex":[0.9990039,0.000119227,0.0001606449,0.0001532346,0.0003134158,0.000249619],"domain_scores_gemma":[0.9994641,0.00002479532,0.0000325515,0.0002359248,0.000191807,0.00005083835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008008419,0.000009755616,0.000484129,0.00003035933,0.000009681576,8.657789e-7,0.0002000536,0.000008743546,0.9746363,0.0002971711,0.0121735,0.01206939],"study_design_scores_gemma":[0.0002673155,0.0001137513,0.002862271,0.00002180997,0.000001676074,9.093443e-7,0.0003384428,0.0001156619,0.9139408,0.0001207299,0.08216529,0.00005132529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952984,0.001299762,0.00007815723,0.001803097,0.0001357725,0.0002945707,0.00002112944,0.00001012556,0.00105897],"genre_scores_gemma":[0.9939944,0.003205768,0.00001251753,0.0000246153,0.0001663381,0.0001163645,0.00007206509,0.00001030131,0.002397602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06999178,"threshold_uncertainty_score":0.171352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04429623205560875,"score_gpt":0.358375543595772,"score_spread":0.3140793115401632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}