{"id":"W4387536668","doi":"10.1016/j.celrep.2023.113222","title":"The mesodermal and myogenic specification of hESCs depend on ZEB1 and are inhibited by ZEB2","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Agencia Estatal de Investigación; Agència de Gestió d'Ajuts Universitaris i de Recerca; Lillehei Heart Institute, University of Minnesota; Universität Zürich; Generalitat de Catalunya; Ministerio de Ciencia e Innovación; BC Children's Hospital; West Virginia University; University of Minnesota; Centres de Recerca de Catalunya; Duchenne Parent Project; European Regional Development Fund; Fundación Cellex","keywords":"Downregulation and upregulation; Embryonic stem cell; Biology; Cell biology; Gene knockdown; Genetics; Cell culture; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001319247,0.0004138555,0.0002004107,0.0002405055,0.0001736532,0.0002690569,0.0001305523,0.0001722544,0.001799081],"category_scores_gemma":[0.0001207839,0.0002622953,0.000208771,0.0001480302,0.0001798885,0.0002001371,0.0002809887,0.0004102235,0.0008302658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002225532,"about_ca_system_score_gemma":0.0001825878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000552991,"about_ca_topic_score_gemma":0.001153574,"domain_scores_codex":[0.9998651,0.00001826169,0.0000131392,0.00002876298,0.00004686558,0.00002794876],"domain_scores_gemma":[0.9999123,0.0000192745,0.00002897355,0.00001115881,0.000009745658,0.0000185943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000481924,0.000006460363,0.0003793864,0.00003488155,0.000006066039,0.00004147295,0.000009171035,0.00009879068,0.9977027,0.0002855225,0.00007672459,0.001310726],"study_design_scores_gemma":[0.00001356891,0.00003637849,0.004549449,0.000005954589,0.000008372271,0.0001836808,0.00001339809,0.0009370591,0.9849471,0.0000677641,0.009233548,0.000003781167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9664084,0.004831039,0.01665723,0.0002297835,0.0000506388,0.00006816347,0.001282971,0.0002688392,0.01020294],"genre_scores_gemma":[0.9779034,0.002474083,0.005009556,0.0001218467,0.00001274747,0.0001055888,0.001911129,0.000109347,0.01235226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001799081,"threshold_uncertainty_score":0.006018519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01142955612987745,"score_gpt":0.2410288374760115,"score_spread":0.2295992813461341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}