{"id":"W4387537862","doi":"10.3390/cancers15204928","title":"Colorectal Cancer Is Borrowing Blueprints from Intestinal Ontogenesis","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Stem cell; Biology; Cancer stem cell; Cancer research; Colorectal cancer; LGR5; Cancer; Tumor initiation; Bioinformatics; Cell biology; Carcinogenesis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002342803,0.000220382,0.0002959106,0.0005609893,0.0004569649,0.001137012,0.0002029945,0.0005748851,0.002304841],"category_scores_gemma":[0.0003791084,0.0001626686,0.0002162263,0.0004471093,0.001271542,0.0009704058,0.0008639325,0.001363864,0.0007010071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005103406,"about_ca_system_score_gemma":0.0009839119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001106208,"about_ca_topic_score_gemma":0.002535905,"domain_scores_codex":[0.9998068,0.00003756211,0.000009806552,0.00004363918,0.0000711617,0.00003105683],"domain_scores_gemma":[0.9997376,0.00005792849,0.00005222504,0.00003579301,0.00004527639,0.00007117767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0005003165,0.00008730777,0.01266581,0.001540529,0.00005959207,0.002958615,0.001147643,0.0007001918,0.5145023,0.09979138,0.01000297,0.3560434],"study_design_scores_gemma":[0.0000335326,0.000728854,0.08076097,0.0004379539,0.00008070541,0.01091948,0.001280787,0.0008167399,0.09807146,0.02643535,0.7803521,0.00008212689],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4742455,0.1913889,0.06851579,0.05108976,0.003028755,0.0001566691,0.001502384,0.001901778,0.2081704],"genre_scores_gemma":[0.8171645,0.1122692,0.01938074,0.007652888,0.001187302,0.00006760525,0.0006291537,0.0002957128,0.04135285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002304841,"threshold_uncertainty_score":0.007710516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04038277920905048,"score_gpt":0.317129127619707,"score_spread":0.2767463484106565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}