{"id":"W4387540360","doi":"10.3390/vaccines11101580","title":"The Expression Kinetics and Immunogenicity of Lipid Nanoparticles Delivering Plasmid DNA and mRNA in Mice","year":2023,"lang":"en","type":"article","venue":"Vaccines","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; University of Ottawa; Health Canada","funders":"Health Canada; Government of Canada","keywords":"Immunogenicity; Plasmid; Messenger RNA; Kinetics; DNA; Molecular biology; Chemistry; Cell biology; Biology; Gene; Immunology; Antigen; Biochemistry; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004810284,0.000406719,0.0002370071,0.0004197857,0.00008348513,0.0002989133,0.0002031508,0.0003521417,0.0005332667],"category_scores_gemma":[0.0004071619,0.0001873624,0.0002923799,0.0001787096,0.0002589473,0.0003466001,0.0001287653,0.0007099318,0.0003697997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004080601,"about_ca_system_score_gemma":0.0002231569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008492072,"about_ca_topic_score_gemma":0.0005049711,"domain_scores_codex":[0.9997661,0.0000415971,0.0000182229,0.00005834141,0.00005551358,0.00006024649],"domain_scores_gemma":[0.9996876,0.00008043821,0.0001004515,0.00002258874,0.00006385472,0.00004505359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003596806,0.00005342271,0.0002455577,0.00002152004,0.000005930431,0.00001701223,0.00003411705,0.0001975671,0.9971431,0.00006820844,0.00002854427,0.001825333],"study_design_scores_gemma":[0.00002085508,0.001572507,0.002519516,0.000005065128,0.00002000275,0.00005768469,0.00002156005,0.002251554,0.9929596,0.00005207354,0.000511847,0.000007793496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899552,0.001137179,0.006662041,0.0001030779,0.00002741319,0.00004813038,0.0002737151,0.0001169886,0.001676202],"genre_scores_gemma":[0.9905488,0.0009039624,0.004373101,0.00009863538,0.00001592284,0.00008300293,0.0004918883,0.00004813986,0.003436549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008492072,"threshold_uncertainty_score":0.002960622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009902897018787007,"score_gpt":0.2319544002128424,"score_spread":0.2220515031940554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}