{"id":"W4387540360","doi":"10.3390/vaccines11101580","title":"The Expression Kinetics and Immunogenicity of Lipid Nanoparticles Delivering Plasmid DNA and mRNA in Mice","year":2023,"lang":"en","type":"article","venue":"Vaccines","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; University of Ottawa; Health Canada","funders":"Health Canada; Government of Canada","keywords":"Immunogenicity; Plasmid; Messenger RNA; Kinetics; DNA; Molecular biology; Chemistry; Cell biology; Biology; Gene; Immunology; Antigen; Biochemistry; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008783732,0.00006523295,0.00006988338,0.00002571614,0.00004395416,0.00001331535,0.00007958407,0.00004418322,0.000001507492],"category_scores_gemma":[0.00004855422,0.00004700771,0.00001705635,0.00006544408,0.00002589345,0.000003465509,0.0001547992,0.00002765787,0.000001391669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001666219,"about_ca_system_score_gemma":0.00000615736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003105785,"about_ca_topic_score_gemma":0.00009081006,"domain_scores_codex":[0.9995635,0.00002155463,0.000134439,0.0001295912,0.0000379377,0.0001129899],"domain_scores_gemma":[0.9997818,0.0000282335,0.00003651842,0.0001046358,0.0000287509,0.00002001908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000970676,0.00000832513,0.008744599,0.00001168905,0.000007580572,7.397831e-7,0.00007405331,0.00002382597,0.9886599,0.00000244288,0.0002123077,0.002157461],"study_design_scores_gemma":[0.0002438114,0.0001089853,0.04292602,0.00002697259,0.000003539943,0.000003855691,0.0001554364,0.0001553041,0.955496,0.00002913516,0.0007945538,0.0000563568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977958,0.00195008,0.00000361777,0.00009630264,0.00006464936,0.00005148185,0.000003981324,0.000005218623,0.00002888294],"genre_scores_gemma":[0.9954741,0.004356965,0.0000329364,0.00001856556,0.00004408952,0.000005188661,0.000004595837,0.000005643304,0.00005794298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03418142,"threshold_uncertainty_score":0.1916919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009902897018787007,"score_gpt":0.2319544002128424,"score_spread":0.2220515031940554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}