{"id":"W4387540598","doi":"10.1016/j.cell.2023.09.008","title":"Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability","year":2023,"lang":"en","type":"article","venue":"Cell","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; Université de Sherbrooke; Université Laval; Hospital for Sick Children; SickKids Foundation; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Genentech; Ministry of Education, Culture, Sports, Science and Technology; Ontario Genomics Institute; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; National Institutes of Health; National Ataxia Foundation; Ontario Genomics; Genome Canada; McGill University; Pfizer; Bristol-Myers Squibb; Bayer; Hereditary Disease Foundation","keywords":"Biology; DNA repair; Trinucleotide repeat expansion; DNA; DNA replication; Spinocerebellar ataxia; DNA damage; Cell biology; Replication protein A; Phenotype; Genetics; DNA-binding protein; Neuroscience; Ataxia; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008148538,0.0004915271,0.0005118448,0.0006295498,0.0003306359,0.001186311,0.0005877057,0.0005245329,0.001586671],"category_scores_gemma":[0.0006353484,0.0002365058,0.000293891,0.0002160203,0.0007939682,0.0005824241,0.0008715567,0.0006532015,0.0005452909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000411841,"about_ca_system_score_gemma":0.0002758426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001637207,"about_ca_topic_score_gemma":0.0005822062,"domain_scores_codex":[0.9992962,0.0001262053,0.00008992879,0.000166897,0.0001730442,0.0001476281],"domain_scores_gemma":[0.9993961,0.000124854,0.0001170097,0.00007724059,0.00008250322,0.00020231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002822374,0.00002297334,0.001417387,0.0000280085,0.00001345736,0.0004120991,0.00002673568,0.00006125195,0.9939161,0.001263416,0.00008144056,0.002474879],"study_design_scores_gemma":[0.0001580109,0.001089935,0.1036766,0.00004175189,0.0001250235,0.01398527,0.000624454,0.007575408,0.8596175,0.005788108,0.007238652,0.00007934798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910247,0.003138394,0.002888716,0.0001746942,0.00004710822,0.000008493897,0.0001516591,0.0000584131,0.002507872],"genre_scores_gemma":[0.9971079,0.0003986218,0.001574093,0.00007058964,0.00002342318,0.00001163686,0.0001184533,0.00002321711,0.000672085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001586671,"threshold_uncertainty_score":0.005307972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03396023020752839,"score_gpt":0.2754504889454806,"score_spread":0.2414902587379522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}