{"id":"W4387540598","doi":"10.1016/j.cell.2023.09.008","title":"Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability","year":2023,"lang":"en","type":"article","venue":"Cell","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; Université de Sherbrooke; Université Laval; Hospital for Sick Children; SickKids Foundation; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Genentech; Ministry of Education, Culture, Sports, Science and Technology; Ontario Genomics Institute; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; National Institutes of Health; National Ataxia Foundation; Ontario Genomics; Genome Canada; McGill University; Pfizer; Bristol-Myers Squibb; Bayer; Hereditary Disease Foundation","keywords":"Biology; DNA repair; Trinucleotide repeat expansion; DNA; DNA replication; Spinocerebellar ataxia; DNA damage; Cell biology; Replication protein A; Phenotype; Genetics; DNA-binding protein; Neuroscience; Ataxia; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001451318,0.0001234033,0.0001870153,0.00008098423,0.00006157945,0.00002056961,0.000162918,0.00002906633,0.0000235828],"category_scores_gemma":[0.001468024,0.000118938,0.0000432088,0.0003749116,0.0002323373,0.00004448714,0.0001385054,0.00009380859,0.00001327577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004561228,"about_ca_system_score_gemma":0.0001201926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004828371,"about_ca_topic_score_gemma":0.0001829884,"domain_scores_codex":[0.9984909,0.0003116117,0.0002431973,0.0004709517,0.0002389118,0.0002443813],"domain_scores_gemma":[0.9991152,0.0003769977,0.00008294993,0.0002423816,0.00003083608,0.0001516404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005736975,0.0003306259,0.3272705,0.00005728215,0.000002309868,0.0001439892,0.0003363036,0.0008431155,0.6705469,0.0001505413,0.00009644982,0.0001645455],"study_design_scores_gemma":[0.0004920122,0.00004747854,0.4833848,0.0000163555,0.00001099656,4.553639e-7,0.00003712244,0.002504263,0.5126597,0.000662205,0.00007485826,0.0001097205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987646,0.00007941658,0.000004392828,0.0001086186,0.0001043973,0.0002102937,0.0001847263,0.00004397133,0.0004995439],"genre_scores_gemma":[0.9995186,0.0001158013,0.000005475387,0.0001023942,0.00001322233,0.00001688722,0.000009649159,0.00001431894,0.0002036095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1578872,"threshold_uncertainty_score":0.4850152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03396023020752839,"score_gpt":0.2754504889454806,"score_spread":0.2414902587379522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}