{"id":"W4387557738","doi":"10.1016/j.jacadv.2023.100648","title":"The Long-Term Efficacy and Safety of Evinacumab in Patients With Homozygous Familial Hypercholesterolemia","year":2023,"lang":"en","type":"article","venue":"JACC Advances","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Chicoutimi","funders":"Regeneron Pharmaceuticals","keywords":"Familial hypercholesterolemia; Medicine; LDL receptor; Internal medicine; Adverse effect; PCSK9; Gastroenterology; Endocrinology; Lipoprotein; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009004805,0.000261033,0.0008809076,0.0001831043,0.0002796729,0.0004510098,0.00017142,0.0004331521,0.0006126317],"category_scores_gemma":[0.000870654,0.0001248308,0.0005193757,0.0001900652,0.0002422785,0.000364433,0.0002046103,0.000743112,0.000159191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003224362,"about_ca_system_score_gemma":0.0003278108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002784023,"about_ca_topic_score_gemma":0.0006468472,"domain_scores_codex":[0.9996686,0.000140025,0.00003477454,0.00004708456,0.00004999216,0.0000594762],"domain_scores_gemma":[0.9995303,0.0001291794,0.0001436066,0.00003396289,0.00003240231,0.0001305786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.3468217,0.009804849,0.2519501,0.000878061,0.002600639,0.001280381,0.000420531,0.001451408,0.03321247,0.0002426654,0.002684029,0.3486531],"study_design_scores_gemma":[0.04792198,0.2307966,0.7009079,0.0002104151,0.002077521,0.002293888,0.0004153044,0.00234048,0.005742296,0.0003625228,0.006852814,0.00007826024],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948993,0.004246154,0.00008928294,0.00009203963,0.00001824283,0.00003035342,0.0001028787,0.000008263147,0.000513382],"genre_scores_gemma":[0.9983858,0.0008565762,0.00009821002,0.0001570814,0.00004158093,0.00003545995,0.000220286,0.000001713148,0.0002034439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009004805,"threshold_uncertainty_score":0.004762232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00793164021826354,"score_gpt":0.2631819293066048,"score_spread":0.2552502890883413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}