{"id":"W4387562887","doi":"10.1002/cam4.6589","title":"Selinexor for the treatment of recurrent or metastatic salivary gland tumors: Results from the <scp>GEMS</scp>‐001 clinical trial","year":2023,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Salivary Gland Tumors Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Sociedad Española de Oncología Médica; Princess Margaret Cancer Foundation; Karyopharm Therapeutics; Adenoid Cystic Carcinoma Research Foundation","keywords":"Medicine; Adenoid cystic carcinoma; Acinic cell carcinoma; Internal medicine; Salivary duct carcinoma; Dysgeusia; Adverse effect; Carcinoma; Gastroenterology; Carcinoma ex pleomorphic adenoma; Clinical endpoint; Oncology; Salivary gland; Pleomorphic adenoma; Clinical trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001463488,0.000661212,0.000992131,0.0001925621,0.0001580994,0.0005831401,0.0002915126,0.0004818947,0.002003012],"category_scores_gemma":[0.0005814723,0.0001454542,0.00105503,0.0001744031,0.0003309832,0.0004336813,0.0002102835,0.00100495,0.0002654076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004084516,"about_ca_system_score_gemma":0.0005727608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003580627,"about_ca_topic_score_gemma":0.00141295,"domain_scores_codex":[0.9997644,0.0001210302,0.0000181689,0.00003188923,0.00003086157,0.00003375966],"domain_scores_gemma":[0.999638,0.00007787897,0.00009450527,0.00002380724,0.00002242981,0.0001434981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5798997,0.01211068,0.02474798,0.002424459,0.003871197,0.0005244367,0.0003555966,0.003939932,0.03658861,0.0004496963,0.007760173,0.3273275],"study_design_scores_gemma":[0.5132937,0.3650784,0.0937942,0.0002887135,0.002818282,0.001298536,0.0001733286,0.00315664,0.007546483,0.0004945667,0.01199177,0.00006537972],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916139,0.005230952,0.0001846616,0.0003818631,0.00005077856,0.0003769433,0.0006544432,0.00003917256,0.00146731],"genre_scores_gemma":[0.991321,0.003469842,0.0005212744,0.0005722219,0.0001026228,0.0004098684,0.00222268,0.00001320439,0.001367434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002003012,"threshold_uncertainty_score":0.007739782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2460746880662434,"score_gpt":0.4520381901877465,"score_spread":0.2059635021215031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}