{"id":"W4387563115","doi":"10.1158/2159-8290.cd-23-0559","title":"Combined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti–PD-1 Monotherapy: A Report from the International RRD Consortium","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Research Manitoba; Research Institute in Oncology and Hematology; Princess Margaret Cancer Centre; Mount Sinai Hospital; Children's Hospital Research Institute of Manitoba; CancerCare Manitoba; Université Laval; Hospital for Sick Children; Centre Hospitalier Universitaire Sainte-Justine; London Health Sciences Centre; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; Hospital for Sick Children; Stand Up To Cancer; St. Baldrick's Foundation","keywords":"Immune system; Immunotherapy; Medicine; Immune checkpoint; Nivolumab; Tumor microenvironment; Cancer research; Adverse effect; Oncology; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000549247,0.0003715039,0.0004280499,0.0001484838,0.0001282648,0.0003066983,0.0002076488,0.0001748515,0.00053578],"category_scores_gemma":[0.0003738386,0.00005837872,0.0003021593,0.0001314681,0.0002420477,0.0001585831,0.0001187101,0.0004387245,0.0001387106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002703972,"about_ca_system_score_gemma":0.0001938797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004620159,"about_ca_topic_score_gemma":0.0006668348,"domain_scores_codex":[0.9998722,0.00004108581,0.00001370813,0.00003038545,0.00001817148,0.00002443426],"domain_scores_gemma":[0.9998292,0.00004758406,0.00003768429,0.00002963225,0.00001582689,0.00004012096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.06739853,0.005727547,0.1147852,0.0009121073,0.001837618,0.001223985,0.0006059186,0.002589519,0.2872033,0.0002436983,0.003320634,0.514152],"study_design_scores_gemma":[0.008726726,0.2002282,0.6008916,0.0001060963,0.00287679,0.007581303,0.0002545529,0.002903598,0.1648359,0.0002167747,0.01130945,0.00006895644],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964806,0.002582881,0.0001725492,0.00007954217,0.00001069491,0.00002074525,0.00006858213,0.00001831888,0.0005660052],"genre_scores_gemma":[0.9986022,0.0006382762,0.0002255412,0.00006210231,0.00001985339,0.00001429612,0.0002016837,0.00000564794,0.0002303902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000549247,"threshold_uncertainty_score":0.002904713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03873460319393386,"score_gpt":0.3358603133968818,"score_spread":0.2971257102029479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}