{"id":"W4387563115","doi":"10.1158/2159-8290.cd-23-0559","title":"Combined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti–PD-1 Monotherapy: A Report from the International RRD Consortium","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Research Manitoba; Research Institute in Oncology and Hematology; Princess Margaret Cancer Centre; Mount Sinai Hospital; Children's Hospital Research Institute of Manitoba; CancerCare Manitoba; Université Laval; Hospital for Sick Children; Centre Hospitalier Universitaire Sainte-Justine; London Health Sciences Centre; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; Hospital for Sick Children; Stand Up To Cancer; St. Baldrick's Foundation","keywords":"Immune system; Immunotherapy; Medicine; Immune checkpoint; Nivolumab; Tumor microenvironment; Cancer research; Adverse effect; Oncology; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003141233,0.0002628932,0.0004342305,0.0001230381,0.0001923053,0.0001458309,0.0002501699,0.00008620976,0.00006930746],"category_scores_gemma":[0.0001401737,0.0001786002,0.0004037913,0.0003226276,0.0001006294,0.0001842445,0.00006276095,0.000115911,0.00001995862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002982595,"about_ca_system_score_gemma":0.0002048573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001857341,"about_ca_topic_score_gemma":0.00007911842,"domain_scores_codex":[0.9978752,0.00002536532,0.000647857,0.0007179748,0.0004078458,0.000325761],"domain_scores_gemma":[0.9979224,0.0003900114,0.00033286,0.001134117,0.0001476608,0.00007294873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001078755,0.0008525963,0.6652796,0.00005811454,0.002308881,0.0002680297,0.0006138701,0.0002331635,0.2996683,0.001510452,0.02312626,0.005002047],"study_design_scores_gemma":[0.009826378,0.0002817922,0.8666549,0.0002148663,0.0003599793,0.00003771427,0.0006293577,0.001759606,0.08607465,0.00100118,0.03274693,0.00041268],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752251,0.001804635,0.0002519966,0.01883324,0.001602834,0.00140186,0.0005596302,0.0002675835,0.00005311531],"genre_scores_gemma":[0.9928874,0.0008407046,0.0002800705,0.00179315,0.0004409078,0.001830242,0.0008200325,0.00006689639,0.001040629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2135936,"threshold_uncertainty_score":0.7283106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03873460319393386,"score_gpt":0.3358603133968818,"score_spread":0.2971257102029479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}