{"id":"W4387575448","doi":"10.1002/jex2.116","title":"Polarized desmosome and hemidesmosome shedding via small extracellular vesicles is an early indicator of outer blood‐retina barrier dysfunction","year":2023,"lang":"en","type":"article","venue":"Journal of Extracellular Biology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Eye Institute; Foundation Fighting Blindness; Pro Retina-Stiftung; Research to Prevent Blindness","keywords":"Desmosome; Vesicle; Extracellular vesicles; Cell biology; Extracellular; Tight junction; Biology; Chemistry; Membrane; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001534009,0.0004436331,0.000687753,0.00043854,0.0001616601,0.00005275799,0.0006059302,0.0006962619,0.0001360727],"category_scores_gemma":[0.0003095697,0.0004185692,0.0003844833,0.0003131865,0.0005028307,0.00004918627,0.0002563825,0.0004654359,0.00002005795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002291911,"about_ca_system_score_gemma":0.0001795282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001859936,"about_ca_topic_score_gemma":0.000004538128,"domain_scores_codex":[0.9966373,0.0004420292,0.001317984,0.0006763953,0.0002918427,0.000634491],"domain_scores_gemma":[0.9972984,0.0001007723,0.001132964,0.0006959212,0.000272767,0.000499134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004564004,0.000234741,0.05912414,0.0001062455,0.0003199642,0.000191426,0.0002418847,0.0000120167,0.9373509,0.0001301754,0.0000759367,0.001756115],"study_design_scores_gemma":[0.002696292,0.00236411,0.009077453,0.0001545012,0.00040824,0.0005101343,0.0002191693,0.0002537553,0.9806535,0.00132684,0.001732551,0.0006034449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754837,0.01618417,0.007357699,0.0001368178,0.0004166825,0.0003065811,0.0000596991,0.00003075415,0.0000238804],"genre_scores_gemma":[0.9939368,0.000865609,0.003828658,0.00009840798,0.0005416088,0.00001179648,0.0001206742,0.00009171398,0.0005047733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05004669,"threshold_uncertainty_score":0.9998266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01396744772947075,"score_gpt":0.2479248554170499,"score_spread":0.2339574076875792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}