{"id":"W4387590066","doi":"10.1016/j.ijrobp.2023.08.028","title":"Primary Endpoint Results of NRG CC003: Phase IIR/III Trial of Prophylactic Cranial Irradiation (PCI) with or without Hippocampal Avoidance (HA) for Small Cell Lung Cancer (SCLC)","year":2023,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Prophylactic cranial irradiation; Conventional PCI; Clinical endpoint; Internal medicine; Hazard ratio; Randomized controlled trial; Lung cancer; Proportional hazards model; Oncology; Surgery; Confidence interval; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002182821,0.002138304,0.002331534,0.0003624653,0.0004538113,0.001326991,0.001014661,0.001392856,0.01052439],"category_scores_gemma":[0.002092615,0.0003489052,0.002899846,0.000512647,0.000681013,0.0007836068,0.0003608017,0.003635906,0.001632761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001305865,"about_ca_system_score_gemma":0.001880407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002918395,"about_ca_topic_score_gemma":0.007600368,"domain_scores_codex":[0.999278,0.0003677966,0.00003359576,0.0001177336,0.00007642973,0.0001264325],"domain_scores_gemma":[0.9988784,0.0002938572,0.000243944,0.0000878608,0.00009140253,0.0004044037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9549492,0.003448385,0.001279466,0.001092727,0.002022871,0.00004108485,0.00004063998,0.001655934,0.003368572,0.0001912928,0.008367234,0.02354257],"study_design_scores_gemma":[0.8190989,0.1476696,0.01881212,0.0001823945,0.003850097,0.0001457329,0.0000665501,0.001529311,0.001823738,0.0009772609,0.005791391,0.00005280868],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9376369,0.01233064,0.001440741,0.002249717,0.0009861134,0.004197068,0.02374969,0.0005430586,0.01686623],"genre_scores_gemma":[0.9576134,0.003862552,0.001550156,0.002444942,0.0006771291,0.003573086,0.01690036,0.0001616334,0.01321674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01052439,"threshold_uncertainty_score":0.03520757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03592922631862843,"score_gpt":0.3672160955283718,"score_spread":0.3312868692097433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}