{"id":"W4387590066","doi":"10.1016/j.ijrobp.2023.08.028","title":"Primary Endpoint Results of NRG CC003: Phase IIR/III Trial of Prophylactic Cranial Irradiation (PCI) with or without Hippocampal Avoidance (HA) for Small Cell Lung Cancer (SCLC)","year":2023,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Prophylactic cranial irradiation; Conventional PCI; Clinical endpoint; Internal medicine; Hazard ratio; Randomized controlled trial; Lung cancer; Proportional hazards model; Oncology; Surgery; Confidence interval; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001020141,0.0002583128,0.0009036922,0.0002736263,0.00006571513,0.00001413138,0.0002510982,0.0001746486,0.00002837427],"category_scores_gemma":[0.0003707628,0.0001850516,0.0003055636,0.0003038887,0.0001828609,0.0001855739,0.00003652741,0.0003269914,0.000002702759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007229724,"about_ca_system_score_gemma":0.001981702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006129919,"about_ca_topic_score_gemma":0.00002735821,"domain_scores_codex":[0.9974471,0.000245758,0.001289734,0.0003099665,0.0004370364,0.0002703833],"domain_scores_gemma":[0.9950365,0.0008417237,0.002652,0.0002028316,0.001132685,0.0001342122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6999547,0.007849674,0.03926979,0.0005457044,0.003835629,0.0002019635,0.002748705,0.003956721,0.02953161,0.001328344,0.002761406,0.2080157],"study_design_scores_gemma":[0.8596316,0.0535974,0.01718492,0.0005746934,0.003069727,0.000279313,0.0004486775,0.02057653,0.02968176,0.002462929,0.01182351,0.0006689549],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834371,0.0003161431,0.009903662,0.001867812,0.001944493,0.001598772,0.000726215,0.00003272089,0.0001731013],"genre_scores_gemma":[0.9890543,0.0005136427,0.00723658,0.0002716626,0.002179828,0.0001088051,0.0004295687,0.00004153331,0.0001641314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2073468,"threshold_uncertainty_score":0.7546183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03592922631862843,"score_gpt":0.3672160955283718,"score_spread":0.3312868692097433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}