{"id":"W4387595270","doi":"10.1126/science.ade9516","title":"Comparative transcriptomics reveals human-specific cortical features","year":2023,"lang":"en","type":"article","venue":"Science","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":194,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Division of Emerging Frontiers; U.S. National Library of Medicine; Nancy and Buster Alvord Endowment; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Genentech; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Human Genome Research Institute; National Alliance for Research on Schizophrenia and Depression; National Institutes of Health; National Science Foundation","keywords":"Marmoset; Neocortex; Macaque; Biology; Human brain; Callithrix; Neuroscience; Gorilla; Rhesus macaque; Transcriptome; Primate; Lineage (genetic); Microglia; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000482019,0.0001285452,0.0001493389,0.0002737711,0.00100414,0.0002459292,0.0005709907,0.00002993241,0.0001088186],"category_scores_gemma":[0.0001977305,0.0001162449,0.0000468858,0.00201886,0.0006322106,0.0004122898,0.00006893387,0.0002132172,0.0009715409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002696224,"about_ca_system_score_gemma":0.00005869726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":2.973166e-7,"about_ca_topic_score_gemma":0.000001513249,"domain_scores_codex":[0.9978797,0.0001320736,0.0002385855,0.000629754,0.0007168268,0.000403085],"domain_scores_gemma":[0.9992355,0.0001439316,0.00006203339,0.0003277843,0.00006283288,0.0001679529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000501624,0.00001290512,0.00000732324,0.000001724792,1.650115e-7,0.00001448043,0.0004045896,0.00007320061,0.8807826,0.1165038,0.002104701,0.00008945287],"study_design_scores_gemma":[0.0001652169,0.00005169989,0.005119499,0.000004410937,0.000001235941,0.00002090882,0.00006920896,0.000856585,0.9868103,0.003412908,0.003355519,0.0001325277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925429,0.000007687152,0.0004107911,0.0007275387,0.0007921123,0.0002485639,0.00001078443,0.0004411716,0.004818437],"genre_scores_gemma":[0.9958312,0.00003519762,0.0001468683,0.001084498,0.00006713777,0.00001473732,0.00000189821,0.000009952987,0.002808499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1130909,"threshold_uncertainty_score":0.9998063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1310879430752438,"score_gpt":0.3544733941303504,"score_spread":0.2233854510551067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}