{"id":"W4387595270","doi":"10.1126/science.ade9516","title":"Comparative transcriptomics reveals human-specific cortical features","year":2023,"lang":"en","type":"article","venue":"Science","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":194,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Division of Emerging Frontiers; U.S. National Library of Medicine; Nancy and Buster Alvord Endowment; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Genentech; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Human Genome Research Institute; National Alliance for Research on Schizophrenia and Depression; National Institutes of Health; National Science Foundation","keywords":"Marmoset; Neocortex; Macaque; Biology; Human brain; Callithrix; Neuroscience; Gorilla; Rhesus macaque; Transcriptome; Primate; Lineage (genetic); Microglia; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478323,0.0001524636,0.0002124109,0.0005508258,0.0001991539,0.0003099993,0.00009948943,0.0001894685,0.001018621],"category_scores_gemma":[0.000258435,0.0001050096,0.0001403465,0.0004025395,0.0002934218,0.0001260443,0.0001821904,0.0001482289,0.0001820154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001215766,"about_ca_system_score_gemma":0.000147866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001424031,"about_ca_topic_score_gemma":0.003806135,"domain_scores_codex":[0.9998894,0.00001072335,0.000005137369,0.0000575315,0.00001856891,0.00001859056],"domain_scores_gemma":[0.9999145,0.00002438553,0.00002197436,0.00001292781,0.00001625119,0.000009955654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001853454,0.000006484785,0.01956319,0.0001125276,0.00006504397,0.0003487796,0.000292023,0.0001718315,0.9699459,0.0002782117,0.0001308692,0.008899775],"study_design_scores_gemma":[0.00001029877,0.0001201992,0.8655176,0.00004062297,0.0001152177,0.002913444,0.0006600377,0.001143192,0.1199419,0.0008249697,0.008688574,0.00002405408],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921823,0.001777712,0.002560853,0.00005875906,0.000007534361,0.000007716719,0.001679159,0.00003464765,0.001691194],"genre_scores_gemma":[0.9945094,0.0008361524,0.002119798,0.00005790253,0.000007221356,0.00002065528,0.00176861,0.00001883064,0.0006615462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001424031,"threshold_uncertainty_score":0.003407598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1310879430752438,"score_gpt":0.3544733941303504,"score_spread":0.2233854510551067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}