{"id":"W4387597413","doi":"10.1007/s00262-023-03520-5","title":"PD-1 and PD-L1 inhibitors in cold colorectal cancer: challenges and strategies","year":2023,"lang":"en","type":"review","venue":"Cancer Immunology Immunotherapy","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; University of Toronto; Western University","funders":"Canadian Institutes of Health Research","keywords":"Colorectal cancer; Medicine; Immunotherapy; Oncology; Cancer; Internal medicine; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0005631456,0.001108068,0.003530737,0.000896466,0.0001838559,0.00009923936,0.0003643092,0.001339343,0.0001867756],"category_scores_gemma":[0.00002455476,0.0009467243,0.0004580921,0.0007439865,0.001180018,0.0002298293,0.0001543873,0.001315514,0.00001812304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008630687,"about_ca_system_score_gemma":0.001771213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001945284,"about_ca_topic_score_gemma":0.001435519,"domain_scores_codex":[0.9958894,0.0003403198,0.00134248,0.001205004,0.0002772562,0.0009455052],"domain_scores_gemma":[0.9981302,0.0003876313,0.0006411308,0.0006251243,0.0001026147,0.0001132868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001804185,0.0001030692,0.00008824962,0.007226752,0.003385468,0.00009229016,0.001349833,2.513001e-7,0.00192928,0.0002587516,0.0002966196,0.9834653],"study_design_scores_gemma":[0.005158722,0.0008284677,0.00359827,0.02278052,0.0005484202,0.0002557878,0.001013212,0.000001637401,0.000171441,0.00008647787,0.9645759,0.0009811274],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009066676,0.9854714,5.6985e-7,0.0008071782,0.001634871,0.002324945,0.0001474588,0.000236185,0.0003107265],"genre_scores_gemma":[0.0003934613,0.9952515,0.00002201249,0.0002227246,0.0003318354,0.002686064,0.00005312314,0.000282819,0.000756507],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9824841,"threshold_uncertainty_score":0.9999571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06282607383926041,"score_gpt":0.3628216248640533,"score_spread":0.2999955510247929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}