{"id":"W4387599119","doi":"10.1111/acel.14000","title":"Carnitine acetyltransferase deficiency mediates mitochondrial dysfunction‐induced cellular senescence in dermal fibroblasts","year":2023,"lang":"en","type":"article","venue":"Aging Cell","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Ministry of Science and ICT, South Korea; Seoul National University Hospital","keywords":"Senescence; Biology; Mitochondrion; Oxidative stress; Cell biology; DNA damage; Mitochondrial DNA; Endocrinology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001752798,0.0003420511,0.0002111331,0.0002162696,0.0001900169,0.0002327774,0.0001590236,0.0001906437,0.001244842],"category_scores_gemma":[0.00009273268,0.0001506263,0.0002525729,0.0001325825,0.0001917256,0.0001499186,0.0002012397,0.0004002351,0.0003881973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002446999,"about_ca_system_score_gemma":0.0002112288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009817854,"about_ca_topic_score_gemma":0.001355688,"domain_scores_codex":[0.9998643,0.00001972997,0.00001786456,0.00004001859,0.00002790539,0.0000300901],"domain_scores_gemma":[0.9998959,0.00001198813,0.00002953207,0.00001812414,0.0000118796,0.00003245926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000769106,0.000017985,0.000165367,0.00002148652,0.000004733228,0.00005922991,0.000008837042,0.00001634094,0.9991633,0.00003261632,0.00002660475,0.0004065164],"study_design_scores_gemma":[0.00004112416,0.0003731003,0.01165279,0.00001291651,0.00003320971,0.0006414707,0.00007206394,0.001286058,0.9827577,0.0000670708,0.003055071,0.000007503636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936521,0.001947804,0.002502545,0.00009251225,0.00003711965,0.0000331629,0.0005074731,0.00008128301,0.001145993],"genre_scores_gemma":[0.9960381,0.0009321102,0.0008791878,0.00004883344,0.000006607773,0.00003727467,0.0003743671,0.00001119926,0.001672336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001244842,"threshold_uncertainty_score":0.004164398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0164078867688727,"score_gpt":0.2456513590165895,"score_spread":0.2292434722477168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}