{"id":"W4387603358","doi":"10.3389/fimmu.2023.1258691","title":"Immunotherapy with STING and TLR9 agonists promotes synergistic therapeutic efficacy with suppressed cancer-associated fibroblasts in colon carcinoma","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Leids Universitair Medisch Centrum; Ferdowsi University of Mashhad; Universiteit Leiden","keywords":"Tumor microenvironment; Cancer research; Immune system; TLR9; Immunotherapy; Medicine; Innate immune system; Immunology; Downregulation and upregulation; Biology; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000132791,0.0003348936,0.0003798768,0.0002336706,0.00008621776,0.0001315195,0.0001006628,0.0001836059,0.0006861338],"category_scores_gemma":[0.00007849573,0.0001130406,0.0002338884,0.000128692,0.0001529037,0.0001302383,0.0001425743,0.0005086726,0.0001685156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001222072,"about_ca_system_score_gemma":0.0002326944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002910305,"about_ca_topic_score_gemma":0.0007680258,"domain_scores_codex":[0.9999126,0.00002162701,0.000008000172,0.0000121423,0.00002305286,0.00002266448],"domain_scores_gemma":[0.9999427,0.000009283262,0.00001285952,0.00000767137,0.000004373358,0.00002313257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007764273,0.0004433797,0.0002731581,0.00006926081,0.000009195096,0.00007799926,0.00002247613,0.0002100931,0.9930507,0.00003570682,0.00006846675,0.00496304],"study_design_scores_gemma":[0.0002251793,0.009265911,0.006581492,0.00001338308,0.0000577044,0.0004619957,0.00004486328,0.00260427,0.9780698,0.00005295218,0.002613969,0.000008606286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977788,0.0009596052,0.000484914,0.0000542219,0.00002958973,0.00003970843,0.00005617217,0.0000342341,0.000562774],"genre_scores_gemma":[0.9971815,0.0007528556,0.001098572,0.00003635007,0.0000151242,0.00004370661,0.00009146933,0.000004544437,0.0007759256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006861338,"threshold_uncertainty_score":0.002295375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009879294689158186,"score_gpt":0.2349894349372945,"score_spread":0.2251101402481363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}