{"id":"W4387605383","doi":"10.1101/2023.10.09.559446","title":"Accelerated brain change in healthy adults is associated with genetic risk for Alzheimer’s disease and uncovers adult lifespan memory decline","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; IXICO; H. Lundbeck A/S; Servier; Universitetet i Oslo; Universitair Medisch Centrum Groningen; Eisai; GGZ Friesland; Genentech; Norges Forskningsråd; Vrije Universiteit Amsterdam; Rivierduinen; ZonMw; Bristol-Myers Squibb; Rijksuniversiteit Groningen; Commonwealth Scientific and Industrial Research Organisation; Northern California Institute for Research and Education; GGZ Drenthe; F. Hoffmann-La Roche; University of Southern California; Pfizer; BioClinica; Biogen; National Institutes of Health; GGZ inGeest; U.S. Department of Defense; Eli Lilly and Company; Universiteit Leiden; Leids Universitair Medisch Centrum; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Alzheimer's Association","keywords":"Ageing; Psychology; Entorhinal cortex; Atrophy; Hippocampus; Brain size; Cognitive decline; Amygdala; Neurodegeneration; Disease; Neuroscience; Dementia; Alzheimer's disease; Medicine; Internal medicine; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004272627,0.0002292434,0.0002720908,0.0006721033,0.0001987669,0.000318564,0.0001438539,0.0002429721,0.001424471],"category_scores_gemma":[0.001050122,0.0001107559,0.0003936517,0.0004431509,0.0001757419,0.0002066783,0.000305062,0.0003125252,0.0001623246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001306644,"about_ca_system_score_gemma":0.0001156402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003903158,"about_ca_topic_score_gemma":0.005316034,"domain_scores_codex":[0.9998842,0.00002658759,0.00001254814,0.00004525734,0.00001525701,0.00001611338],"domain_scores_gemma":[0.9995171,0.00007560869,0.0001954642,0.00009386342,0.00005674149,0.00006129241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000524967,0.00006169554,0.9784634,0.00001982397,0.000202727,0.0001589133,0.0001201379,0.0005023378,0.01085059,0.00009666912,0.0002607461,0.008738101],"study_design_scores_gemma":[0.000002984739,0.0000803304,0.9980707,0.000002818194,0.00002200782,0.0001599146,0.00003174347,0.000892075,0.0004880817,0.0001568057,0.00009001231,0.000002511756],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988027,0.00006729911,0.000523256,0.0000213844,0.000001778028,0.000003211836,0.0004126836,0.00001307869,0.0001545853],"genre_scores_gemma":[0.9990739,0.00002552193,0.0003660798,0.00001207154,0.000002644507,0.000003995814,0.0003941101,0.000002863045,0.0001188617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003903158,"threshold_uncertainty_score":0.007760882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0511066581131512,"score_gpt":0.3065400622990899,"score_spread":0.2554334041859387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}