{"id":"W4387621169","doi":"10.1161/res.133.suppl_1.p1027","title":"Abstract P1027: Confocal And Mass Spectrometry-based Investigation Of REEP5 Depletion By AAV9 In The Mouse Heart","year":2023,"lang":"en","type":"article","venue":"Circulation Research","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Cell biology; Endoplasmic reticulum; Vacuolization; Biology; Cytosol; Cardiac fibrosis; Gene knockin; Organelle; Zebrafish; Internal medicine; Endocrinology; Fibrosis; Biochemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001384663,0.00005772611,0.00007616061,0.000194134,0.00007048852,0.0000235836,0.00008227477,0.0001338062,0.00005098242],"category_scores_gemma":[0.0003113226,0.00005076803,0.00002670859,0.000461227,0.00014497,0.000004811273,0.00001836609,0.0001602039,0.00002018061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001256832,"about_ca_system_score_gemma":0.00005983821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006177998,"about_ca_topic_score_gemma":0.00003499614,"domain_scores_codex":[0.9988691,0.0003094726,0.0001728349,0.0002133254,0.0002667198,0.0001685876],"domain_scores_gemma":[0.9995127,0.0001022781,0.00003585189,0.0002046192,0.0001033417,0.00004114981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004214698,0.00001028197,0.05524364,0.00001882506,0.000002936934,0.00000101037,0.00004716387,0.0002915548,0.938347,0.0001016533,0.005819269,0.00007453766],"study_design_scores_gemma":[0.001158182,0.0002968432,0.6690279,0.00001517733,0.000004310082,0.000006798571,0.0003666093,0.004698669,0.3176795,0.0008209407,0.005773049,0.0001520258],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966236,0.00007708688,0.00141217,0.001210043,0.00004276774,0.0002536137,0.00001381249,0.000008977388,0.0003579716],"genre_scores_gemma":[0.9989599,0.00003058799,0.0001461347,0.0001571036,0.00007029072,0.00002651587,0.0004847439,0.000008169169,0.0001165319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6206675,"threshold_uncertainty_score":0.207026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06156517887846388,"score_gpt":0.339453674553556,"score_spread":0.2778884956750922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}