{"id":"W4387647049","doi":"10.1016/j.ygyno.2023.09.013","title":"A randomized phase 2 study of sapanisertib in combination with paclitaxel versus paclitaxel alone in women with advanced, recurrent, or persistent endometrial cancer","year":2023,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute; Eisai; Seagen; Takeda Pharmaceuticals U.S.A.; Clovis Oncology; AstraZeneca; Bristol-Myers Squibb","keywords":"Paclitaxel; Medicine; Hazard ratio; Endometrial cancer; Internal medicine; Clinical endpoint; Chemotherapy; Gastroenterology; Randomized controlled trial; Urology; Confidence interval; Oncology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001936544,0.001657336,0.002507711,0.0005105174,0.0003425456,0.0008536181,0.0007727318,0.001506678,0.009033794],"category_scores_gemma":[0.001815384,0.0009046851,0.001406066,0.0003833258,0.0009614327,0.00109207,0.0004220687,0.002679355,0.001097479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007402707,"about_ca_system_score_gemma":0.001421245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000508211,"about_ca_topic_score_gemma":0.001595987,"domain_scores_codex":[0.9993287,0.0004145457,0.00002820537,0.0001042733,0.00004540092,0.00007886604],"domain_scores_gemma":[0.9991207,0.0002521456,0.0002150164,0.00006916113,0.000046714,0.000296322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9681952,0.01276625,0.0006012787,0.0003034045,0.0005209909,0.00004005343,0.00004671551,0.0003331307,0.003289972,0.00008186389,0.0006068579,0.01321432],"study_design_scores_gemma":[0.8751907,0.1224413,0.0008731385,0.0000125127,0.0001952761,0.00003207124,0.00001567323,0.0003072875,0.0002964062,0.000111796,0.0005139905,0.000009742951],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872679,0.00235713,0.0007076963,0.0007424342,0.0005714916,0.005612218,0.0008877262,0.0001038077,0.001749592],"genre_scores_gemma":[0.9765407,0.002241089,0.002723906,0.001599329,0.0006554085,0.01013348,0.001260343,0.00003941617,0.004806291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009033794,"threshold_uncertainty_score":0.03022105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06679682524608217,"score_gpt":0.3854782519070304,"score_spread":0.3186814266609482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}