{"id":"W4387652169","doi":"10.1101/2023.10.14.562322","title":"Repression of mRNA translation initiation by GIGYF1 via blocking the eIF3-eIF4G1 interaction","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Dalhousie University; University of Toronto; University of Ottawa; Children's Hospital of Eastern Ontario; McGill University","funders":"Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Canadian Institutes of Health Research; China Scholarship Council; National Research Foundation of Korea; National Research Foundation","keywords":"Translation (biology); Biology; Messenger RNA; Cell biology; Eukaryotic initiation factor; Initiation factor; Eukaryotic translation; Translational regulation; RNA-binding protein; Protein biosynthesis; EIF4E; P-bodies; Internal ribosome entry site; Psychological repression; Molecular biology; Gene expression; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001625579,0.0004027967,0.0002741876,0.0001572787,0.0001781729,0.0002547158,0.0003376746,0.0003086648,0.001675847],"category_scores_gemma":[0.0001312648,0.0001193408,0.0002635912,0.0000997597,0.000213806,0.0001306666,0.0002563603,0.0007125112,0.0006062941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004291135,"about_ca_system_score_gemma":0.0002218803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004035408,"about_ca_topic_score_gemma":0.000550688,"domain_scores_codex":[0.9998757,0.00001152253,0.000009131738,0.00003404689,0.00003012915,0.00003942833],"domain_scores_gemma":[0.9999093,0.00001479069,0.00003102318,0.00001139564,0.000006161521,0.00002735709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001203047,0.00002046442,0.0003169499,0.00004354831,0.000006087681,0.00005408619,0.000006848083,0.0001047545,0.997507,0.0001351113,0.0001101392,0.001574758],"study_design_scores_gemma":[0.00002059727,0.0001395302,0.003397158,0.000007051067,0.000009798871,0.000238539,0.00001709868,0.001220163,0.988474,0.00005889637,0.0064107,0.000006516173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990335,0.003294026,0.003502388,0.0002207774,0.00009343934,0.00003240598,0.0006173086,0.0001517689,0.001752862],"genre_scores_gemma":[0.9936332,0.0007733836,0.00252923,0.0001075702,0.00002113062,0.00004328592,0.000963187,0.0000337396,0.001895271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001675847,"threshold_uncertainty_score":0.005606234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0209268562868153,"score_gpt":0.2540159600584371,"score_spread":0.2330891037716218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}