{"id":"W4387664554","doi":"10.1101/2023.10.12.561697","title":"Small molecule STAT3/5 inhibitors exhibit therapeutic potential in acute myeloid leukemia and extra-nodal natural killer/T cell lymphoma","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Veterinärmedizinische Universität Wien","keywords":"Cancer research; Myeloid leukemia; Biology; Cytarabine; Tyrosine kinase; Myeloid; Leukemia; Immunology; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009095883,0.0002411105,0.000127679,0.0001622256,0.00005331924,0.0001468851,0.0001186439,0.0001488273,0.001222507],"category_scores_gemma":[0.00004013838,0.00006420066,0.0001657678,0.00009795815,0.00009581199,0.00009373973,0.00009415344,0.0003327978,0.0002051391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001323451,"about_ca_system_score_gemma":0.0001246004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002846181,"about_ca_topic_score_gemma":0.0007688679,"domain_scores_codex":[0.9999579,0.000007759444,0.000003497792,0.00000582855,0.00001299247,0.00001201693],"domain_scores_gemma":[0.999975,0.000004613314,0.000006884983,0.000002392338,0.000002941907,0.000008080935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002977481,0.0001264152,0.0002559338,0.00007831831,0.00001481931,0.00005889942,0.000008801665,0.0003141396,0.9895965,0.0001494859,0.0001798704,0.008918947],"study_design_scores_gemma":[0.000163372,0.004122167,0.003859753,0.000007790236,0.00005124349,0.0004931776,0.00001466729,0.001563555,0.9830513,0.00005272161,0.006614676,0.000005630324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886004,0.006460984,0.002099134,0.00009848305,0.00003492382,0.00005556413,0.0002666943,0.0001103863,0.002273491],"genre_scores_gemma":[0.9940192,0.002168874,0.001367262,0.00005036732,0.000008130044,0.00003112917,0.0003854116,0.000008042194,0.001961609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001222507,"threshold_uncertainty_score":0.004089713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01723929904295849,"score_gpt":0.2391417452261828,"score_spread":0.2219024461832243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}