{"id":"W4387665951","doi":"10.1371/journal.ppat.1011735","title":"SARS-CoV-2 suppresses TLR4-induced immunity by dendritic cells via C-type lectin receptor DC-SIGN","year":2023,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; ZonMw; European Research Council; Universität Innsbruck; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Österreichischen Akademie der Wissenschaften","keywords":"Immune system; DC-SIGN; TLR4; Immunology; Biology; Inflammation; HMGB1; Lipopolysaccharide; Cytokine storm; Receptor; Interferon; Microbiology; Dendritic cell; Medicine; Infectious disease (medical specialty); Disease; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001539349,0.0002974847,0.0002755517,0.0001233696,0.000103984,0.0002402046,0.0001510139,0.0002371435,0.0009069532],"category_scores_gemma":[0.0001110819,0.0001042029,0.0002642547,0.00008761822,0.0001997166,0.0001334357,0.0001544525,0.0005712779,0.0003427145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001761475,"about_ca_system_score_gemma":0.0002646887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003583932,"about_ca_topic_score_gemma":0.0005089127,"domain_scores_codex":[0.9998054,0.00005239401,0.00001965836,0.00002401771,0.00003026751,0.00006822254],"domain_scores_gemma":[0.9999344,0.00001111768,0.00001496513,0.00001014851,0.000009793242,0.00001948548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002530528,0.00006356317,0.0001404794,0.00003285296,0.000002448496,0.00002767492,0.00001080018,0.00003340933,0.9986559,0.00003058961,0.00003130627,0.0007177793],"study_design_scores_gemma":[0.000116011,0.001283291,0.006186502,0.00000892817,0.00001333459,0.0001934908,0.00003716291,0.001312321,0.9886814,0.00004788474,0.002114878,0.000004798616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972951,0.0006727601,0.0006387878,0.00008940751,0.00002685868,0.00003973299,0.0001906718,0.00004228728,0.001004385],"genre_scores_gemma":[0.9967592,0.0004692895,0.0008721096,0.0001148413,0.00001904101,0.00004644989,0.0003779518,0.0000104654,0.001330644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009069532,"threshold_uncertainty_score":0.003034055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07628960281203308,"score_gpt":0.3392258003397669,"score_spread":0.2629361975277338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}