{"id":"W4387665951","doi":"10.1371/journal.ppat.1011735","title":"SARS-CoV-2 suppresses TLR4-induced immunity by dendritic cells via C-type lectin receptor DC-SIGN","year":2023,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; ZonMw; European Research Council; Universität Innsbruck; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Österreichischen Akademie der Wissenschaften","keywords":"Immune system; DC-SIGN; TLR4; Immunology; Biology; Inflammation; HMGB1; Lipopolysaccharide; Cytokine storm; Receptor; Interferon; Microbiology; Dendritic cell; Medicine; Infectious disease (medical specialty); Disease; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006006401,0.0004051279,0.0006263172,0.0004015896,0.000308293,0.00009866567,0.0005435848,0.0003319353,0.0001256464],"category_scores_gemma":[0.0009500792,0.0003881576,0.0002212535,0.00163777,0.0001312041,0.0001382952,0.0002803849,0.0008231988,0.004990151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002016059,"about_ca_system_score_gemma":0.0003727355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003112065,"about_ca_topic_score_gemma":0.00004069429,"domain_scores_codex":[0.9963463,0.0003566591,0.0004835626,0.0006855155,0.001049907,0.001078052],"domain_scores_gemma":[0.9978004,0.0005784765,0.00009261614,0.001002479,0.0004079748,0.0001181009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002687105,0.0005659684,0.004851618,0.0002471826,0.0001699316,0.0002640847,0.0004801736,1.067818e-7,0.9573215,0.000004650115,0.03465063,0.001175444],"study_design_scores_gemma":[0.001111761,0.0006463843,0.0006644985,0.0001253896,0.0001397394,0.00003027653,0.0002086677,0.0001852493,0.9524733,0.00008254212,0.04395325,0.0003789352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955363,0.0003323336,0.00004063658,0.0003702502,0.0008313534,0.0008537266,0.00008069402,0.000585128,0.001369533],"genre_scores_gemma":[0.989489,0.00005791958,0.0001914859,0.00893791,0.000361111,0.0001242996,0.0001075542,0.000156665,0.0005740731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009302619,"threshold_uncertainty_score":0.999857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07628960281203308,"score_gpt":0.3392258003397669,"score_spread":0.2629361975277338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}