{"id":"W4387665952","doi":"10.1371/journal.pgen.1010977","title":"Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits","year":2023,"lang":"en","type":"review","venue":"PLoS Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Nursing Research","keywords":"Genome-wide association study; Mendelian randomization; Biology; Quantitative trait locus; Genetics; Genetic association; Expression quantitative trait loci; Genetic architecture; Chronic pain; Candidate gene; Multifactorial Inheritance; Gene; Single-nucleotide polymorphism; Genotype; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005020016,0.0009531489,0.001194602,0.002267054,0.0007095068,0.001450094,0.0007208167,0.0008158374,0.002408111],"category_scores_gemma":[0.007164813,0.0004235987,0.003640143,0.0036093,0.0007405949,0.000431931,0.001272828,0.001113112,0.0001710784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003037798,"about_ca_system_score_gemma":0.0004843165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006543681,"about_ca_topic_score_gemma":0.006853235,"domain_scores_codex":[0.99418,0.00285792,0.000473364,0.001616967,0.0004846955,0.000387088],"domain_scores_gemma":[0.9917393,0.005243439,0.001444589,0.0009580289,0.0002866995,0.0003279167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002985302,0.00006355106,0.9439093,0.0002893829,0.02543169,0.00127835,0.0002544732,0.001777192,0.008067687,0.0006151255,0.0006927789,0.01463501],"study_design_scores_gemma":[0.000258228,0.0002727711,0.9756033,0.00005902599,0.01310609,0.001305338,0.0002154003,0.005683247,0.00119802,0.001137902,0.001123365,0.00003730968],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9837824,0.005567917,0.008094707,0.0004369318,0.00005104374,0.00001874096,0.001275406,0.0001377926,0.0006351378],"genre_scores_gemma":[0.9969257,0.0005532734,0.001734298,0.00005348252,0.00002019038,0.00001423129,0.0004913346,0.00002118326,0.0001861703],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.006543681,"threshold_uncertainty_score":0.02654874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0582990364418512,"score_gpt":0.2950568241038495,"score_spread":0.2367577876619983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}