{"id":"W4387665952","doi":"10.1371/journal.pgen.1010977","title":"Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits","year":2023,"lang":"en","type":"review","venue":"PLoS Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Nursing Research","keywords":"Genome-wide association study; Mendelian randomization; Biology; Quantitative trait locus; Genetics; Genetic association; Expression quantitative trait loci; Genetic architecture; Chronic pain; Candidate gene; Multifactorial Inheritance; Gene; Single-nucleotide polymorphism; Genotype; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002812207,0.0004841932,0.001825591,0.0002427177,0.0003454277,0.00005275229,0.0001950986,0.001069327,0.00000717609],"category_scores_gemma":[0.004449782,0.0003926813,0.0004748438,0.0005719519,0.0001058308,0.000003091683,0.0001490882,0.0004392949,0.000005421841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008570698,"about_ca_system_score_gemma":0.0001489777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009474895,"about_ca_topic_score_gemma":0.0003860428,"domain_scores_codex":[0.995374,0.001921359,0.001023435,0.0009715559,0.000191146,0.0005184652],"domain_scores_gemma":[0.9967845,0.00113234,0.001199934,0.0004898163,0.0002448261,0.0001486051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006826151,0.0003722638,0.8732532,0.005005675,0.02569623,0.000002245742,0.000183938,0.0004313665,0.0002974741,0.00007732418,0.001689734,0.09292223],"study_design_scores_gemma":[0.0008893237,0.001023886,0.6593426,0.0001760259,0.02597059,0.000005448655,0.0001142966,0.0005515594,0.00001035563,0.00122182,0.3094699,0.001224184],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08601715,0.9082816,0.003412707,0.0001327144,0.00003914987,0.001399315,0.0006713882,0.00003162369,0.00001431415],"genre_scores_gemma":[0.006120226,0.9829078,0.008330591,0.00006444409,0.000243337,0.0003266127,0.001654327,0.00007084659,0.0002818194],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3077802,"threshold_uncertainty_score":0.9998525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0582990364418512,"score_gpt":0.2950568241038495,"score_spread":0.2367577876619983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}