{"id":"W4387675632","doi":"10.1016/j.neubiorev.2023.105425","title":"Major depressive disorder as a neuro-immune disorder: Origin, mechanisms, and therapeutic opportunities","year":2023,"lang":"en","type":"review","venue":"Neuroscience & Biobehavioral Reviews","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Universidade do Extremo Sul Catarinense; Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Neuroinflammation; Major depressive disorder; Inflammation; Antidepressant; Pathophysiology; Systemic inflammation; Neuroscience; Immune system; Mechanism (biology); Medicine; Sickness behavior; Psychoneuroimmunology; Psychology; Immunology; Bioinformatics; Biology; Amygdala; Internal medicine; Hippocampus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005442265,0.0008883228,0.001582491,0.001465949,0.0002392186,0.001298224,0.0008768447,0.001037437,0.002975559],"category_scores_gemma":[0.0004789563,0.000195231,0.0003707607,0.001870509,0.0004480411,0.001109462,0.0006961769,0.001695693,0.001443953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000610017,"about_ca_system_score_gemma":0.001256426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001254513,"about_ca_topic_score_gemma":0.003792626,"domain_scores_codex":[0.9998778,0.00002503339,0.00001625777,0.00002113472,0.00004322718,0.00001651458],"domain_scores_gemma":[0.9997731,0.0001014533,0.00003684131,0.000006359553,0.00005361763,0.00002865507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001322546,0.0001029726,0.0002378263,0.01405563,0.0001149843,0.0002665803,0.00005652604,0.0003560485,0.002016831,0.004663037,0.03043106,0.9475663],"study_design_scores_gemma":[0.00004919905,0.0001507347,0.001511313,0.006832348,0.0002152563,0.00209536,0.0001226974,0.0001614535,0.0003598664,0.003917563,0.9845542,0.00003003602],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005168011,0.9993204,0.00003855016,0.0001670974,0.00008756359,0.000001529755,0.000007241426,0.000002329606,0.000323597],"genre_scores_gemma":[0.0002807298,0.999307,0.0000623012,0.00008590059,0.00009435188,0.000002133392,0.000008209674,3.915667e-7,0.0001590178],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002975559,"threshold_uncertainty_score":0.009954214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2331093375326192,"score_gpt":0.3935273562222917,"score_spread":0.1604180186896725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}