{"id":"W4387692503","doi":"10.15252/embr.202356815","title":"The HACE1 E3 ligase mediates RAC1‐dependent control of mTOR signaling complexes","year":2023,"lang":"en","type":"article","venue":"EMBO Reports","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; T. Von Zastrow Foundation; Österreichischen Akademie der Wissenschaften; National Science Foundation; Conquer Cancer Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Ubiquitin ligase; mTORC1; mTORC2; PI3K/AKT/mTOR pathway; RAC1; Chemistry; Ubiquitin; Cell biology; Mechanistic target of rapamycin; Biochemistry; Biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003513845,0.0003480841,0.0002650172,0.0002858946,0.0005209355,0.0009252121,0.0003628543,0.0004339011,0.00279392],"category_scores_gemma":[0.0003174289,0.00024851,0.0002325675,0.0001813645,0.0004263333,0.0006210663,0.0005653234,0.0007284766,0.001360651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001089603,"about_ca_system_score_gemma":0.0003580509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008578643,"about_ca_topic_score_gemma":0.001345214,"domain_scores_codex":[0.9997779,0.00002465046,0.00001195146,0.00006024209,0.00004890245,0.00007649932],"domain_scores_gemma":[0.9998511,0.00001844778,0.0000322816,0.00002494852,0.00002964669,0.00004345414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003142431,0.00003128853,0.0009439677,0.00007130068,0.00001908559,0.0001481985,0.00003738852,0.000266656,0.9881841,0.003492787,0.0006606909,0.005830224],"study_design_scores_gemma":[0.00001308186,0.00002060779,0.003066198,0.00000277078,0.000005004437,0.0002126957,0.00002542338,0.001893761,0.9884453,0.000230302,0.006079612,0.000005356851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747753,0.004647698,0.009335605,0.00118994,0.0001063612,0.00003366976,0.0006503848,0.0002817118,0.008979381],"genre_scores_gemma":[0.990597,0.0007013231,0.001893399,0.00009938338,0.00001576344,0.00001556733,0.0004473526,0.00004167457,0.006188698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00279392,"threshold_uncertainty_score":0.009346545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01167189884213558,"score_gpt":0.2649476354009561,"score_spread":0.2532757365588205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}