{"id":"W4387692503","doi":"10.15252/embr.202356815","title":"The HACE1 E3 ligase mediates RAC1‐dependent control of mTOR signaling complexes","year":2023,"lang":"en","type":"article","venue":"EMBO Reports","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; T. Von Zastrow Foundation; Österreichischen Akademie der Wissenschaften; National Science Foundation; Conquer Cancer Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Ubiquitin ligase; mTORC1; mTORC2; PI3K/AKT/mTOR pathway; RAC1; Chemistry; Ubiquitin; Cell biology; Mechanistic target of rapamycin; Biochemistry; Biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009457945,0.0001692564,0.0002326612,0.00004004885,0.000155172,0.00003522632,0.0002493682,0.0001223126,0.00004193776],"category_scores_gemma":[0.0006727031,0.0001293907,0.0001478707,0.0001261334,0.0001402092,0.000003654912,0.0001547581,0.0001040493,0.00001344127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001909834,"about_ca_system_score_gemma":0.0001479955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004394032,"about_ca_topic_score_gemma":0.00002385108,"domain_scores_codex":[0.9983337,0.00007982425,0.0005286356,0.0003772473,0.0003487378,0.0003318679],"domain_scores_gemma":[0.9985417,0.0001312574,0.0003867258,0.0006830404,0.0001654683,0.00009177739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005919173,0.00002388073,0.004295907,0.00002202455,0.0001359475,0.0001515802,0.00005630947,0.001115222,0.9830316,0.00002138271,0.01036126,0.0007256438],"study_design_scores_gemma":[0.0003688828,0.0001285297,0.001070809,0.00003079194,0.00004067504,0.00007665712,0.00009841627,0.0001965814,0.9702324,0.0004955257,0.02708015,0.0001805255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948048,0.002740633,0.0003128088,0.0004265717,0.0008776674,0.0002627755,0.00003066754,0.00005200972,0.0004920852],"genre_scores_gemma":[0.9979821,0.0001593369,0.00007201534,0.0001416591,0.0004984479,0.0000600352,0.00007875461,0.00003448056,0.0009731162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01671889,"threshold_uncertainty_score":0.5276397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01167189884213558,"score_gpt":0.2649476354009561,"score_spread":0.2532757365588205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}