{"id":"W4387692696","doi":"10.4155/bio-2023-0160","title":"Fabry Disease Biomarkers in Patients Switched From Enzyme-Replacement Therapy to Migalastat Oral Chaperone Therapy","year":2023,"lang":"en","type":"article","venue":"Bioanalysis","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Sacré-Cœur de Montréal; Université de Montréal; Queen Elizabeth II Health Sciences Centre; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Dalhousie University; Vancouver General Hospital; University of British Columbia; Université de Sherbrooke","funders":"Amicus Therapeutics","keywords":"Enzyme replacement therapy; Fabry disease; Medicine; Pharmacology; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008940137,0.0002506065,0.0006447342,0.0003790214,0.0004679532,0.0009326498,0.0002315093,0.0004860749,0.0008180552],"category_scores_gemma":[0.001823321,0.000145252,0.0003381875,0.0004606468,0.0002172982,0.0004392096,0.0002556179,0.0005957965,0.0001814569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004691276,"about_ca_system_score_gemma":0.0003197074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001585863,"about_ca_topic_score_gemma":0.001364243,"domain_scores_codex":[0.999621,0.00007148915,0.00003643573,0.0001158798,0.00008117147,0.00007399674],"domain_scores_gemma":[0.9991341,0.0001405336,0.0003566181,0.00005235404,0.0001509837,0.0001653365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004525379,0.000271599,0.973111,0.00002559514,0.0001398416,0.00040402,0.000359854,0.0001088044,0.008234257,0.00002135656,0.0001336767,0.01266466],"study_design_scores_gemma":[0.00009287914,0.003656036,0.992566,0.00001206411,0.0001474447,0.0009610773,0.0002974784,0.0002798778,0.00146316,0.00003936544,0.0004740716,0.00001047353],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995875,0.0001661066,0.00003234161,0.00001792529,0.000002690469,0.000005274539,0.00005272822,0.000002530151,0.0001328966],"genre_scores_gemma":[0.9996122,0.00004871376,0.00005471866,0.00004180061,0.000003684224,0.00000662295,0.0001231391,9.598781e-7,0.0001082159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001585863,"threshold_uncertainty_score":0.004728019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03375076291038707,"score_gpt":0.3107170149396052,"score_spread":0.2769662520292182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}