{"id":"W4387692989","doi":"10.1172/jci.insight.174458","title":"Dormant tumors circumvent tumor-specific adaptive immunity by establishing a Treg-dominated niche via DKK3","year":2023,"lang":"en","type":"article","venue":"JCI Insight","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; London Health Sciences Centre; National Institutes of Health; American Cancer Society; U.S. Department of Defense","keywords":"Immune system; FOXP3; Tumor microenvironment; Cancer research; Biology; Acquired immune system; Immunology; Immunotherapy; CD8; Tumor progression; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003896249,0.0003128356,0.0003895799,0.0003426682,0.0005105521,0.00007267144,0.0003278037,0.0002343698,0.002723359],"category_scores_gemma":[0.00009336945,0.0002836816,0.0001836647,0.0006945831,0.0001557587,0.0004892229,0.0001680821,0.000919722,0.006718535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002153117,"about_ca_system_score_gemma":0.00005479328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004166937,"about_ca_topic_score_gemma":0.00001820951,"domain_scores_codex":[0.9979687,0.0004116207,0.0005384734,0.0004341258,0.0000858309,0.0005612158],"domain_scores_gemma":[0.9988298,0.0002364948,0.0002500924,0.0004885922,0.0001511536,0.00004381682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004172393,0.0002309091,0.0000844367,0.00001076136,0.000129056,0.00003690051,0.001559108,0.00001083922,0.7167722,0.0002138642,0.2758094,0.004725309],"study_design_scores_gemma":[0.001453565,0.0003296884,0.002564257,0.00006642408,0.00002826729,0.0001329165,0.001823987,0.0001566447,0.2812928,0.0000580821,0.7117334,0.0003599672],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.944955,0.005437531,0.001106675,0.0006159992,0.01233978,0.0007509246,0.0000411524,0.001068333,0.0336846],"genre_scores_gemma":[0.9690762,0.0002354083,0.0000101791,0.0003453073,0.00006124643,0.00006367725,0.0009187972,0.00004566439,0.02924353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.435924,"threshold_uncertainty_score":0.9999616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01778838491203982,"score_gpt":0.2232342889378906,"score_spread":0.2054459040258508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}